{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:51:43Z","timestamp":1778910703164,"version":"3.51.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The aim of this study was to identify patients vulnerable for anxiety and\/or depression following aortic valve replacement (AVR) and to evaluate factors that may mitigate this risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This is a retrospective cohort study conducted using a claims database; 18\u00a0990 patients (1\/2013\u201312\/2018) \u226555\u00a0years of age with 6\u00a0months of pre\u2010AVR data were identified. Anxiety and\/or depression risk was compared at 3\u00a0months, 6\u00a0months, and 1\u00a0year following transcatheter aortic valve replacement or surgical AVR (SAVR) after risk adjustment using logistic regression and Cox proportional hazards models. Separate models were estimated for patients with and without surgical complications and discharge location. Patients with SAVR experienced a higher relative risk of anxiety and\/or depression at 3\u00a0months (12.4% versus 8.8%; adjusted hazard ratio [HR] 1.39 [95% CI, 1.19\u20131.63]) and 6\u00a0months (15.6% versus 13.0%; adjusted HR, 1.24 [95% CI, 1.08\u20131.42]), with this difference narrowing by 12\u00a0months (20.1% versus 19.3%; adjusted HR, 1.14 [95% CI, 1.01\u20131.29]) after AVR. This association was most pronounced among patients discharged to home, with patients with SAVR having a higher relative risk of anxiety and\/or depression. In patients who experienced operative complications, there was no difference between SAVR and transcatheter aortic valve replacement. However, among patients without operative complications, patients with SAVR had an increased risk of postoperative anxiety and\/or depression at 3\u00a0months (adjusted HR, 1.47 [95% CI, 1.23\u20131.75]) and 6\u00a0months (adjusted HR 1.26 [95% CI, 1.08\u20131.46]), but not at 12\u00a0months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">There is an associated reduction in the risk of new\u2010onset anxiety and\/or depression among patients undergoing transcatheter aortic valve replacement (versus SAVR), particularly in the first 3 and 6\u00a0months following treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024377","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:47:33Z","timestamp":1650966453000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Anxiety and Depression Following Aortic Valve Replacement"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-2218","authenticated-orcid":false,"given":"Zachary K.","family":"Wegermann","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University Health System Durham NC"},{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-9158","authenticated-orcid":false,"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3367-0302","authenticated-orcid":false,"given":"Suzanne V.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart InstituteUniversity of Missouri\u2010Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-4730","authenticated-orcid":false,"given":"Christin A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences Irvine CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ryan","sequence":"additional","affiliation":[{"name":"MPR Consulting Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-585X","authenticated-orcid":false,"given":"Candace","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Gunnarsson Consulting Jupiter FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Strong","sequence":"additional","affiliation":[{"name":"Heart Valve Voice US Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY"},{"name":"St. Francis Hospital Roslyn NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-1424","authenticated-orcid":false,"given":"Karen P.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University Health System Durham NC"},{"name":"Duke Clinical Research Institute Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7904-285X","authenticated-orcid":false,"given":"J. 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