{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:58:46Z","timestamp":1784235526498,"version":"3.55.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">A multidisciplinary approach might be pivotal for the management of patients with valvular heart disease (VHD), but clinical outcome data are lacking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              At our institution, since 2014, internal guidelines recommended heart team consultations for patients with VHD. The clinical\/echocardiographic characteristics, treatment recommendations, performed treatment, and early clinical outcomes of consecutive, hospitalized patients with VHD undergoing heart team evaluation were collected. Surgical risk was prospectively assessed by the EuroSCORE II and STS\u2010PROM. The primary end point of the study was early mortality. A total of 1004 patients with VHD with high clinical complexity (mean age, 75\u00a0years; mean EuroSCORE II, 9.4%; mean STS\u2010PROM, 5.6%; 48% ischemic heart disease; 29% chronic kidney disease, 9% oncologic\/hematologic diseases) were enrolled. The heart team recommended an interventional treatment for 807 (80%) patients and conservative management for 197 (20%) patients. Management crossovers occurred in only 5% of patients. The recommended intervention was cardiac surgery for 230 (23%) patients, percutaneous treatment in 516 (51%) patients, and hybrid treatment in 61 (6%) patients. Early mortality occurred in 24 patients (2.4%) and was independently predicted by aortic stenosis, left ventricular ejection fraction, pulmonary artery systolic pressure, and conservative management recommendation. In patients referred to treatment, observed early mortality (1.7%) was significantly lower (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) than expected on the bases of both the STS\u2010PROM (5.2%) and EuroSCORE II (9.7%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Within the limitations of its single\u2010center and observational design, the present study suggests that heart team\u2013based management of patients with complex VHD is feasible and allows referral to a wide spectrum of interventions with promising early clinical results.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024404","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T11:08:58Z","timestamp":1653649738000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Impact of Heart Team Decisions for Patients With Complex Valvular Heart Disease: A Large, Single\u2010Center Experience"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9401","authenticated-orcid":false,"given":"Francesco","family":"Burzotta","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. 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