{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:00:32Z","timestamp":1791478832941,"version":"4.3.4"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The aim of this study was to prospectively evaluate the effects of renal artery stenting in consecutive patients with severe atherosclerotic renal artery stenosis and high\u2010risk clinical presentations as defined in a national protocol developed in 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Since the protocol was initiated, 102 patients have been referred for revascularization according to the following high\u2010risk criteria: severe renal artery stenosis (\u226570%) with true resistant hypertension, rapidly declining kidney function, or recurrent heart failure\/sudden pulmonary edema. At baseline, the mean 24\u2010hour ambulatory systolic blood pressure was 166.2\u00a0mm\u00a0Hg (95% CI, 162.0\u2013170.4), the defined daily dose of antihypertensive medication was 6.5 (95% CI, 5.8\u20137.3), and the estimated glomerular filtration rate was 41.1\u00a0mL\/min per 1.73m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI, 36.6\u201345.6). In 96 patients with available 3\u2010month follow\u2010up data, mean 24\u2010hour ambulatory systolic blood pressure decreased by 19.6\u00a0mm\u00a0Hg (95% CI, 15.4\u201323.8;\n                      <jats:italic>P&lt;<\/jats:italic>\n                      0.001), the defined daily dose of antihypertensive medication was reduced by 52% (95% CI, 41%\u201362%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and estimated glomerular filtration rate increased by 7.8\u00a0mL\/min per 1.73m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI, 4.5\u201311.1;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). All changes persisted after 24\u00a0months follow\u2010up. Among 17 patients with a history of hospitalization for acute decompensated heart failure, 14 patients had no new episodes after successful revascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this prospective cohort study, we observed a reduction in blood pressure and antihypertensive medication, an increase in estimated glomerular filtration rate, and a decrease in new hospital admissions attributable to heart failure\/sudden pulmonary edema after renal artery stenting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      . Identifier: NCT02770066.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.024421","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T18:42:54Z","timestamp":1648147374000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Renal Artery Stenting in Consecutive High\u2010Risk Patients With Atherosclerotic Renovascular Disease: A Prospective 2\u2010Center Cohort Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-5036","authenticated-orcid":false,"given":"Mark","family":"Reinhard","sequence":"first","affiliation":[{"name":"Department of Renal Medicine and The Clinic of Hypertension Aarhus University Hospital Denmark"},{"name":"Department of Clinical Medicine Aarhus University 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Radiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-777X","authenticated-orcid":false,"given":"Arindam","family":"Bharadwaz","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-6973","authenticated-orcid":false,"given":"Arne","family":"H\u00f8rlyck","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens K\u00e6rsgaard","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Aarhus University Hospital Aarhus N 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Abildgaard","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\/Steno Diabetes Center Odense and The Clinic of Hypertension Odense University Hospital Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-4076","authenticated-orcid":false,"given":"Bo Martin","family":"Bibby","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Aarhus University Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-4028","authenticated-orcid":false,"given":"Kent Lodberg","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Denmark"},{"name":"Department of Cardiology and The Clinic of Hypertension Aarhus University Hospital 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