{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:40:57Z","timestamp":1790350857187,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data on percutaneous left atrial appendage closure (LAAC) outcomes in the very elderly with atrial fibrillation are limited. We aimed to investigate the clinical characteristics and short\u2010term outcomes of patients 80\u00a0years or older following percutaneous LAAC in a large nationwide database.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using the Nationwide Readmissions Database, we identified patients who underwent percutaneous LAAC between January 2016 and December 2018. Patients were categorized based on age (\u226580 and &lt;80\u00a0years old). The primary outcome was in\u2010hospital mortality. Secondary outcomes were in\u2010hospital end points including periprocedural complications, 30\u2010day outcomes, and all\u2010cause 30\u2010day readmissions. A propensity score\u2013matched model (1:1) was used to adjust for baseline characteristics among the study groups. A total of 13\u00a0208 patients were included in this study (43% women, median age in years [interquartile range] 79.5 [73\u201384]) and matched one\u2010to\u2010one (6604 and 6604 patients were \u226580 and &lt;80\u00a0years old, respectively). In\u2010hospital mortality was not statistically different between the study groups and occurred in 21 patients \u226580\u00a0years old (0.32%) and in 14 patients &lt;80\u00a0years old (0.21%);\n              <jats:italic>P<\/jats:italic>\n              =0.236. Rates of in\u2010hospital stroke\/transient ischemic attack were higher in patients \u226580\u00a0years old compared with those &lt;80 years old (1.22% versus 0.77%;\n              <jats:italic>P<\/jats:italic>\n              =0.009). In\u2010hospital bleeding requiring transfusion, vascular complications, systemic embolization, and pericardial effusion\/tamponade requiring pericardiocentesis or surgical intervention occurred more frequently in patients \u226580\u00a0years old. Furthermore, the elderly group was more likely to be readmitted within 30\u00a0days compared with those &lt;80\u00a0years old (9.91% versus 8.4%;\n              <jats:italic>P<\/jats:italic>\n              =0.004); however, rates of 30\u2010day complications were not statistically different between the study groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In a large nationwide database, patients \u226580\u00a0years old undergoing percutaneous LAAC were found to have similar in\u2010hospital mortality but an increased risk of periprocedural complications and 30\u2010day readmission compared with younger patients. Our data suggest that LAAC should be considered on a case\u2010by\u2010case basis in the very elderly, taking into consideration the risks and benefits of this intervention. Further studies are needed to assess long\u2010term LAAC outcomes in this high\u2010risk population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024574","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T09:15:16Z","timestamp":1659690916000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Short\u2010Term Outcomes Following Left Atrial Appendage Closure in the Very Elderly: A Population\u2010Based Analysis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-9690","authenticated-orcid":false,"given":"Medhat","family":"Farwati","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6447","authenticated-orcid":false,"given":"Toshiaki","family":"Isogai","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-0131","authenticated-orcid":false,"given":"Anas M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-6487","authenticated-orcid":false,"given":"Abdelrahman I.","family":"Abushouk","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-7716","authenticated-orcid":false,"given":"Oussama","family":"Wazni","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000040"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0172"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021973"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.01.026"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140263.20897.42"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_3_1_13_2","unstructured":"Agency for Healthcare Research and Quality . 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