{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:47:14Z","timestamp":1790754434617,"version":"4.1.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patent foramen ovale (PFO)\u2010associated platypnea\u2010orthodeoxia syndrome is characterized by dyspnea and hypoxemia when upright. The pathogenesis is thought to involve an increase in right atrial pressure or change in degree of right to left shunting with upright posture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We sought to characterize patients with platypnea\u2010orthodeoxia syndrome related to PFO without pulmonary hypertension. We retrospectively reviewed databases at 3 tertiary referral hospitals in New South Wales, Australia from 2000 to 2019. Fourteen patients with a mean age of 69\u00b114\u00a0years had a PFO with wide tunnel separation. Mean New York Heart Association Classification was II (\u00b10.9) and 7 inpatients had been confined to bed (from postural symptoms). Baseline oxygen saturations supine were 93%\u00b15% and 84%\u00b16% upright. Two patients had a minor congenital heart defect and 4 had mild parenchymal lung disease with preserved lung function. The mean aortic root diameter was 37\u00b16\u00a0mm and distance between aortic root and posterior atrial wall was 16\u00b12\u00a0mm. Platypnea\u2010orthodeoxia syndrome was preceded by surgery in 5 patients and 1 patient had mild pneumonia. Successful closure of the PFO using an Amplatzer device was performed in 11 of 14 patients. Post\u2010closure, all patients had New York Heart Association Classification I (improvement 1.6\u00b10.9,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.003) and semi\u2010recumbent oxygen saturations increased by 13%\u00b18% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001, n=10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Platypnea\u2010orthodeoxia syndrome is a debilitating condition, curable by PFO closure. Anatomical distortion of the atrial septum related to a dilated aortic root or shortening of the distance between the aortic root and posterior atrial wall may contribute to the syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.024609","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T08:02:58Z","timestamp":1658736178000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Platypnea\u2010Orthodeoxia Syndrome in the Setting of Patent Foramen Ovale Without Pulmonary Hypertension or Major Lung Disease"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-9454","authenticated-orcid":false,"given":"Farrah","family":"Othman","sequence":"first","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-0373","authenticated-orcid":false,"given":"Brian","family":"Bailey","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Collins","sequence":"additional","affiliation":[{"name":"John Hunter Hospital Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Lau","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tanous","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Rao","sequence":"additional","affiliation":[{"name":"Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7640-0439","authenticated-orcid":false,"given":"David","family":"Celermajer","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"Heart Research Institute Sydney NSW Australia"},{"name":"Sydney Medical SchoolUniversity of Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-389X","authenticated-orcid":false,"given":"Rachael","family":"Cordina","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"Heart Research Institute Sydney NSW Australia"},{"name":"Sydney Medical SchoolUniversity of Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61253-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1944"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.07.003"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-004-0035-3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25953"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.09.008"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.024609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:15:34Z","timestamp":1715584534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.024609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":6,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,8,2]]}},"alternative-id":["10.1161\/JAHA.121.024609"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.024609","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"2022-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e024609"}}