{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:16:03Z","timestamp":1790655363881,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The plasma concentration of B\u2010type natriuretic peptide (BNP) is a strong predictor of adverse cardiovascular events. The aim of this study was to determine whether the association between plasma BNP concentration and cardiovascular mortality is sustained or diminishes with increasing time after BNP is measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Six thousand seven hundred forty patients with a history of myocardial infarction or unstable angina who participated in the LIPID (Long\u2010Term Intervention with Pravastatin in Ischemic Disease) trial had plasma BNP concentration measured at baseline and after 1\u2009year. Associations with cardiovascular mortality were evaluated in landmark analyses 1 to &lt;5, 5 to &lt;10, and 10 to 16\u2009years after randomization. There were 1640 cardiovascular deaths. The cardiovascular mortality rate increased progressively from 10.2 to 19.1 to 26.3\/1000\u2009patient\u2010years from 1 to &lt;5, 5 to &lt;10, and 10 to 16\u2009years after baseline, respectively. The average of baseline and 1\u2010year BNP concentration was more strongly associated with cardiovascular mortality compared with baseline or 1\u2010year BNP only. The hazard ratio (HR) for cardiovascular death associated with each doubling of average BNP concentration was similar during years 1 to &lt;5 (HR, 1.53 [95% CI, 1.44\u20131.63]), years 5 to &lt;10 (HR, 1.52 [95% CI, 1.44\u20131.60]), and years 10\u201316 (HR, 1.43 [95% CI, 1.36\u20131.50]),\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001 for all.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">BNP concentration remains an independent predictor of cardiovascular mortality more than a decade after it is measured. Because of random variation in plasma concentrations, the average of &gt;1 BNP measurement improves long\u2010term risk prediction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024616","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T10:46:58Z","timestamp":1656499618000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["B\u2010Type Natriuretic Peptide and Long\u2010Term Cardiovascular Mortality in Patients With Coronary Heart Disease"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-1225","authenticated-orcid":false,"given":"Ralph A. 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