{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:26:03Z","timestamp":1784766363273,"version":"3.55.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc (congestive heart failure, hypertension, age \u226575\u00a0years, diabetes, previous stroke or TIA [transient ischemic attack], vascular disease, age 65 to 74\u00a0years, sex category female; 2 indicates 2 points, otherwise 1 point) scoring system is recommended to guide decisions on oral anticoagulation therapy for stroke prevention in patients with nonsurgery atrial fibrillation. A score \u22651 in men and \u22652 in women, corresponding to an annual stroke risk exceeding 1%, warrants long\u2010term oral anticoagulation provided the bleeding risk is acceptable. However, in patients with new\u2010onset postoperative atrial fibrillation, the optimal risk stratification method is unknown. The aim of this study was therefore to evaluate the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc scoring system for estimating the 1\u2010year ischemic stroke risk in patients with new\u2010onset postoperative atrial fibrillation after coronary artery bypass grafting.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              All patients with new\u2010onset postoperative atrial fibrillation and without oral anticoagulation after first\u2010time isolated coronary artery bypass grafting performed in Sweden during 2007 to 2017 were eligible for this registry\u2010based observational cohort study. The 1\u2010year ischemic stroke rate at each step of the CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc score was estimated using a Kaplan\u2010Meier estimator. Of the 6368 patients included (mean age, 69.9\u00a0years; 81% men), &gt;97% were treated with antiplatelet drugs. There were 147 ischemic strokes during the first year of follow\u2010up. The ischemic stroke rate at 1\u00a0year was 0.3%, 0.7%, and 1.5% in patients with CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc scores of 1, 2, and 3, respectively, and \u22652.3% in patients with a score \u22654. A sensitivity analysis, with the inclusion of patients on anticoagulants, was performed and supported the primary results.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with new\u2010onset atrial fibrillation after coronary artery bypass grafting and a CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              \u2010VASc score &lt;3 have such a low 1\u2010year risk for ischemic stroke that oral anticoagulation therapy should probably be avoided.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024703","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:13:35Z","timestamp":1652692415000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Stroke Risk Stratification in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-4387","authenticated-orcid":false,"given":"Amar","family":"Taha","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Sweden"},{"name":"Department of Cardiology Region V\u00e4stra G\u00f6talandSahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne J.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Sweden"},{"name":"Department of Cardiothoracic Surgery Region V\u00e4stra G\u00f6talandSahlgrenska University Hospital Gothenburg 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