{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:20:51Z","timestamp":1785788451513,"version":"3.56.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is a concern that resheathing\/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications. We aimed to evaluate the short\u2010 and long\u2010term impact on clinical outcomes of resheathing for repositioning of transcatheter heart valves during TAVI procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a systematic search of Embase, MEDLINE, and Cochrane Central Register of Controlled Trials databases to identify studies comparing outcomes between patients requiring resheathing\/repositioning during TAVI and those who did not. Random\u2010effects meta\u2010analyses were used to estimate the association of resheathing compared with no resheathing with clinical outcomes after TAVI. Seven studies including 4501 participants (pooled mean age, 80.9\u00b17.4\u00a0years; 54% women; and 1374 [30.5%] patients requiring resheathing\/repositioning) were included in this study. No significant differences between the 2 groups were identified with regards to safety: 30\u2010day mortality (n=3125; odds ratio [OR], 0.74 [95% confidence interval [CI], 0.41\u20131.33];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%), stroke (n=4121; OR, 1.09 [95% CI, 0.74\u20131.62];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%), coronary obstruction (n=3000; OR, 2.35 [95% CI, 0.17\u201333.47];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =75%), major vascular complications (n=3125; OR, 0.92 [95% CI, 0.66\u20131.33];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%), major bleeding (n=3125; OR, 1.13 [95% CI, 0.94\u20132.01];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =39%), acute kidney injury (n=3495; OR, 1.30 [95% CI, 0.64\u20132.62];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =44%), and efficacy outcomes: device success (n=1196; OR, 0.77 [95% CI, 0.51\u20131.14];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%), need for a second valve (n=3170; OR, 2.86 [95% CI, 0.96\u20138.48];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =62%), significant (moderate or higher) paravalvular leak (n=1151; OR, 1.53 [95% CI, 0.83\u20132.80];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%), and permanent pacemaker implantation (n=1908; OR, 1.04 [95% CI, 0.68\u20131.57];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =58%). One\u2010year mortality was similar between groups (n=1972; OR, 1.00 [95% CI, 0.68\u20131.47];\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Resheathing of transcatheter heart valves during TAVI is associated with similar periprocedural risk compared with no resheathing in several patient\u2010important outcomes. These data support the safety of current self\u2010expanding transcatheter heart valves with resheathing features.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/\">https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n              ; Unique identifier: CRD42021273715.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024707","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T10:35:02Z","timestamp":1655202902000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1403","authenticated-orcid":false,"given":"Francesco","family":"Moroni","sequence":"first","affiliation":[{"name":"Division of Cardiology Pauley Heart CenterVirginia Commonwealth University Richmond VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-0360","authenticated-orcid":false,"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Sondergaard","sequence":"additional","affiliation":[{"name":"The Heart Centre, RigshospitaletCopenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-1242","authenticated-orcid":false,"given":"Guilherme F.","family":"Attizzani","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical Center Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-6783","authenticated-orcid":false,"given":"Santiago","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-358X","authenticated-orcid":false,"given":"Hani","family":"Jneid","sequence":"additional","affiliation":[{"name":"Division of Cardiology Baylor School of Medicine and the Michael E. DeBakey VAMC Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Centre for Prognosis ResearchInstitute of Primary Care and Health SciencesKeele University Stoke\u2010on\u2010Trent United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-9429","authenticated-orcid":false,"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Centre for Prognosis ResearchInstitute of Primary Care and Health SciencesKeele University Stoke\u2010on\u2010Trent United Kingdom"},{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine &amp; Dentistry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2018.1536543"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.014"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2019.1557045"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.08.035"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.06.041"},{"key":"e_1_3_1_7_2","first-page":"282","article-title":"Impact of repositioning during transcatheter aortic valve replacement on embolized debris","volume":"31","author":"Seeger J","year":"2019","unstructured":"Seeger J, Romero M, Schuh C, Virmani R, W\u00f6hrle J. Impact of repositioning during transcatheter aortic valve replacement on embolized debris. J Invasive Cardiol. 2019;31:282\u2013288.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.04.028"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs533"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_1_11_2","article-title":"ROBINS\u2010I: a tool for assessing risk of bias in non\u2010randomised studies of interventions","volume":"355","author":"Sterne JA","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, et al. ROBINS\u2010I: a tool for assessing risk of bias in non\u2010randomised studies of interventions. BMJ. 2016;355:i4919. doi: 10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-106"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.045"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.11.002"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2019.100462"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3070427"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020682"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.06.027"},{"key":"e_1_3_1_21_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021)","author":"Page M","unstructured":"Page M, Higgins J, Sterne J. Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, eds. Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021: Available from www.training.cochrane.org\/handbook. Accessed August 15, 2021"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.10.014"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.05.021"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.03.004"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.004"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000568"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1045"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313356"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022933"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa036"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.024707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:00:46Z","timestamp":1715601646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.024707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,6,21]]}},"alternative-id":["10.1161\/JAHA.121.024707"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.024707","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"2021-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e024707"}}