{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:19:47Z","timestamp":1790507987253,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Several imaging parameters and biomarkers provide diagnostic and prognostic information for wild\u2010type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association with cardiac amyloid load requires further substantiation. We aimed to elucidate the association of imaging parameters obtained using\n              <jats:sup>99m<\/jats:sup>\n              Tc\u2010labeled pyrophosphate scintigraphy, cardiovascular magnetic resonance imaging, global longitudinal strain (GLS), and cardiac biomarkers with cardiac amyloid load in patients with wild\u2010type transthyretin amyloid cardiomyopathy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Eighty\u2010eight patients with wild\u2010type transthyretin amyloid cardiomyopathy who underwent\n              <jats:sup>99m<\/jats:sup>\n              Tc\u2010labeled pyrophosphate scintigraphy and cardiovascular magnetic resonance were retrospectively evaluated. Quantitative cardiac amyloid load was obtained from 61 patients after myocardial biopsy. Correlations were assessed using Pearson\u2019s correlation coefficient applied to medical record data. The mean heart to contralateral ratio, native T1, extracellular volume, and GLS were 1.91\u00b10.36, 1419.4\u00b156.4\u00a0ms, 56.5\u00b113.6%, and \u22129.4\u00b12.5%, respectively. Median high\u2010sensitivity cardiac troponin T (hs\u2010cTnT) and BNP (B\u2010type natriuretic peptide) levels were 0.0478 (0.0334\u20100.0691) ng\/mL and 213.8 (125.8\u2013392.7) pg\/mL, respectively. The mean cardiac amyloid load was 22.9\u00b115.0%. The heart to contralateral ratio correlated significantly with native T1 (\n              <jats:italic>r<\/jats:italic>\n              =0.397), extracellular volume (\n              <jats:italic>r<\/jats:italic>\n              =0.477), GLS (\n              <jats:italic>r<\/jats:italic>\n              =0.363), cardiac amyloid load (\n              <jats:italic>r<\/jats:italic>\n              =0.379), and Ln (hs\u2010cTnT) (\n              <jats:italic>r<\/jats:italic>\n              =0.247). Further, cardiac amyloid load correlated significantly with native T1 (\n              <jats:italic>r<\/jats:italic>\n              =0.509), extracellular volume (\n              <jats:italic>r<\/jats:italic>\n              =0.310), GLS (\n              <jats:italic>r<\/jats:italic>\n              =0.446), and Ln (hs\u2010cTnT) (\n              <jats:italic>r<\/jats:italic>\n              =0.354). Compared with BNP, hs\u2010cTnT levels better correlated with several imaging parameters and cardiac amyloid load.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Increased cardiac amyloid load correlated with increased\n              <jats:sup>99m<\/jats:sup>\n              Tc\u2010labeled pyrophosphate positivity, native T1, extracellular volume, and hs\u2010cTnT levels, and an impaired GLS, suggesting that imaging parameters and cardiac biomarkers may reflect histological and functional changes attributable to amyloid deposition in the myocardium.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024717","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T10:32:58Z","timestamp":1655202778000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild\u2010Type Transthyretin Amyloid Cardiomyopathy"],"prefix":"10.1161","volume":"11","author":[{"given":"Mami","family":"Morioka","sequence":"first","affiliation":[{"name":"Departments of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-0701","authenticated-orcid":false,"given":"Seiji","family":"Takashio","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto 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