{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:24:18Z","timestamp":1792211058156,"version":"4.4.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with ductal\u2010dependent pulmonary blood flow, initial palliation includes catheter\u2010based patent ductus arteriosus (PDA) stent or surgical aortopulmonary shunt (APS). This meta\u2010analysis aimed to compare outcomes between PDA stent and APS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A comprehensive literature search yielded six retrospective observational studies. Pooled adjusted hazard ratios (HR) were included to control for covariates and assess time to event analysis. Of 757 patients, 243 (32.1%) underwent PDA stent and 514 (67.9%) underwent APS. Pulmonary atresia with intact ventricular septum and expected biventricular repair were more common with PDA stent compared with APS (39.6% versus 21.2%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 and 57.9% versus 46.6%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.007, respectively). There was no statistically significant difference in mortality between PDA stent and APS (HR, 0.71; [95% CI, 0.26\u20131.93];\n                      <jats:italic>P<\/jats:italic>\n                      =0.50). PDA stent was associated with lower risk of postprocedural complications (odds ratio [OR], 0.45; [95% CI, 0.25\u20130.81];\n                      <jats:italic>P<\/jats:italic>\n                      =0.008), mechanical circulatory support (OR, 0.27; [95% CI, 0.09\u20130.79];\n                      <jats:italic>P<\/jats:italic>\n                      =0.02), and shorter intensive care unit length of stay (\u22124.03\u2009days; [95% CI, \u22125.99 to \u22122.07];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), hospital length of stay (\u22125.54\u2009days; [95% CI, \u22129.20 to \u22121.88];\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), and duration of mechanical ventilation (\u22123.41\u2009days; [95% CI, \u22125.29 to \u22121.52];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). There was no difference in pulmonary artery growth or hazard of unplanned reintereventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">PDA stent has a similar hazard of mortality compared with APS. Benefits to PDA stent include shorter duration of mechanical ventilation, shorter hospital length of stay, and fewer complications. Differences in patient characteristics exist with more patients with pulmonary atresia with intact ventricular septum and expected biventricular repair undergoing PDA stent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.024721","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T06:40:48Z","timestamp":1656484848000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Patent Ductus Arteriosus Stent Versus Surgical Aortopulmonary Shunt for Initial Palliation of Cyanotic Congenital Heart Disease with Ductal\u2010Dependent Pulmonary Blood Flow: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-3176","authenticated-orcid":false,"given":"Stephanie Y.","family":"Tseng","sequence":"first","affiliation":[{"name":"The Heart Center Nationwide Children\u2019s Hospital Columbus OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vien T.","family":"Truong","sequence":"additional","affiliation":[{"name":"The Christ Hospital Health Network Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Peck","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-2624","authenticated-orcid":false,"given":"Sneha","family":"Kandi","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University Rootstown OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-6538","authenticated-orcid":false,"given":"Samuel","family":"Brayer","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-6939","authenticated-orcid":false,"suffix":"III","given":"Don P.","family":"Jason","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Mazur","sequence":"additional","affiliation":[{"name":"The Christ Hospital Health Network Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-7250","authenticated-orcid":false,"given":"Garick D.","family":"Hill","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awais","family":"Ashfaq","sequence":"additional","affiliation":[{"name":"Heart Institute Johns Hopkins All Children\u2019s Hospital St. Petersburg FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-9523","authenticated-orcid":false,"given":"Bryan H.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"The Heart Institute, UPMC Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-4822","authenticated-orcid":false,"given":"Tarek","family":"Alsaied","sequence":"additional","affiliation":[{"name":"The Heart Institute, UPMC Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine Pittsburgh 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