{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:08:43Z","timestamp":1792422523680,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Electromechanical dyssynchrony is a well described comorbidity in pulmonary arterial hypertension (PAH). ECG\u2010derived measurements reflective of diastolic dysfunction and electromechanical imaging markers are yet to be investigated. In this study we investigated the ECG\u2010 derived marker of repolarization dispersion, interval between the peak and end of T wave (TpTe), in pediatric patients with PAH and left ventricular (LV) diastolic dysfunction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We measured TpTe from a standard 12\u2010lead ECG and in 30 children with PAH and matched control subjects. All participants underwent same\u2010day echocardiography and myocardial strain analysis to calculate the diastolic electromechanical discoordination marker diastolic relaxation fraction. When compared with control subjects, patients with PAH had increased TpTe (93\u00b115 versus 81\u00b112\u00a0ms,\n              <jats:italic>P<\/jats:italic>\n              =0.001) and elevated diastolic relaxation fraction (0.33\u00b10.10 versus 0.27\u00b10.03,\n              <jats:italic>P<\/jats:italic>\n              =0.001). Patients with PAH with LV diastolic dysfunction had significantly increased TpTe when compared with patients with PAH without diastolic dysfunction (\n              <jats:italic>P<\/jats:italic>\n              =0.012) and when compared with control group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Similarly, patients with PAH with LV diastolic dysfunction had increased diastolic relaxation fraction when compared with PAH patients without diastolic dysfunction (\n              <jats:italic>P<\/jats:italic>\n              =0.007) and when compared with control group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). A 10\u2010ms increase in TpTe was significantly associated with 0.023 increase in diastolic relaxation fraction (\n              <jats:italic>P<\/jats:italic>\n              =0.008) adjusting for body surface area, heart rate, right ventricular volumes, and function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Prolonged myocardial repolarization and abnormal LV diastolic electromechanical discoordination exist in parallel in children with PAH and are associated with worse LV diastolic function and functional class.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024787","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:58:37Z","timestamp":1646132317000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-3262","authenticated-orcid":false,"given":"Michal","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-6265","authenticated-orcid":false,"given":"Benjamin S.","family":"Frank","sequence":"additional","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-3402","authenticated-orcid":false,"given":"D. Dunbar","family":"Ivy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max B.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Section of Congenital Heart Surgery Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn K.","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Ni","family":"Jone","sequence":"additional","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.","family":"von Alvensleben","sequence":"additional","affiliation":[{"name":"Division of Cardiology Heart InstituteChildren\u2019s Hospital ColoradoUniversity of Colorado Denver Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00355.2019"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.027"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01031.2005"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.02.009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.04.004"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.01.1308"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00106.2008"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-3-23"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01419-2016"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.232"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.969717"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs251"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.856021"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035326"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0089OC"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2365OC"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201909-1771OC"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.028"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2399"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003607"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001622"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.07.004"},{"key":"e_1_3_1_26_2","first-page":"1","article-title":"3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension","volume":"19","author":"Jone P\u2010N","year":"2017","unstructured":"Jone P\u2010N, Sch\u00e4fer M, Pan Z, Bremen C, Ivy DD. 3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension. 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