{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:37:47Z","timestamp":1773099467512,"version":"3.50.1"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, transplantation in patients with DS is rarely reported. This project aimed to collect and describe waitlist and post\u2013 HTx outcomes in children with DS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is a retrospective case series of children with DS listed for HTx. Pediatric HTx centers were identified by their participation in 2 international registries with centers reporting HTx in a patient with DS providing detailed demographic, medical, surgical, and posttransplant outcome data for analysis. A total of 26 patients with DS were listed for HTx from 1992 to 2020 (median age, 8.5\u00a0years; 46% male). High\u2010risk or failed repair of congenital heart disease was the most common indication for transplant (N=18, 69%). A total of 23 (88%) patients survived to transplant. All transplanted patients survived to hospital discharge with a median posttransplant length of stay of 22\u00a0days. At a median posttransplant follow\u2010up of 2.8\u00a0years, 20 (87%) patients were alive, 2 (9%) developed posttransplant lymphoproliferative disorder, and 8 (35%) were hospitalized for infection within the first year. Waitlist and posttransplant outcomes were similar in patients with and without DS (\n              <jats:italic>P<\/jats:italic>\n              =non\u2010significant for all).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Waitlist and post\u2010HTx outcomes in children with DS selected for transplant listing are comparable to pediatric HTx recipients overall. Given acceptable outcomes, the presence of DS alone should not be considered an absolute contraindication to HTx.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024883","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:14:51Z","timestamp":1652692491000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Heart Transplantation in Children With Down Syndrome"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-0625","authenticated-orcid":false,"given":"Justin","family":"Godown","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Monroe Carell Jr. Children\u2019s Hospital at VanderbiltNashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene","family":"Fountain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Monroe Carell Jr. Children\u2019s 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