{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:26Z","timestamp":1788447746207,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder affecting multiple systems, particularly the cardiovascular system. The leading causes of death in MFS are aortopathies and valvular disease. We wanted to identify the frequency of arrhythmia and postural orthostatic tachycardia syndrome, length of hospital stay, health care\u2013associated costs (HAC), and in\u2010hospital mortality in patients with MFS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The National Inpatient Sample database from 2005 to 2014 was queried using\n              <jats:italic>International Classification of Diseases, Ninth Revision, Clinical Modification<\/jats:italic>\n              (\n              <jats:italic>ICD\u20109\u2010CM<\/jats:italic>\n              ) codes for MFS and arrhythmias. Patients were classified into subgroups: supraventricular tachycardia, ventricular tachycardia (VT), atrial fibrillation, atrial flutter, and without any type of arrhythmia. Data about length of stay, HAC, and in\u2010hospital mortality were also abstracted from National Inpatient Sample database. Adjusted HAC was calculated as multiplying HAC and cost\u2010to\u2010charge ratio; 12\u2009079 MFS hospitalizations were identified; 1893 patients (15.7%) had an arrhythmia; and 4.9% of the patients had postural orthostatic tachycardia syndrome. Median values of length of stay and adjusted HAC in VT group were the highest among the groups (VT: 6\u2009days, $18\u2009975.8; supraventricular tachycardia: 4\u2009days, $11\u2009906.6; atrial flutter: 4\u2009days, $11\u2009274.5; atrial fibrillation: 5\u2009days, $10431.4; without any type of arrhythmia: 4\u2009days, $8336.6; both\n              <jats:italic>P<\/jats:italic>\n              =0.0001). VT group had highest in\u2010patient mortality (VT: 5.3%, atrial fibrillation: 4.1%, without any type of arrhythmia: 2.1%, atrial flutter: 1.7%, supraventricular tachycardia: 0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) even after adjustment for potential confounders (without any type of arrhythmia versus VT; odds ratio [95% CI]: 3.18 [1.62\u20136.24],\n              <jats:italic>P<\/jats:italic>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Arrhythmias and postural orthostatic tachycardia syndrome in MFS were high and associated with increased length of stay, HAC, and in\u2010hospital mortality especially in patients with VT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024939","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:05:03Z","timestamp":1661331903000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Frequency of Arrhythmias and Postural Orthostatic Tachycardia Syndrome in Patients With Marfan Syndrome: A Nationwide Inpatient Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-2632","authenticated-orcid":false,"given":"Syed Emir Irfan","family":"Wafa","sequence":"first","affiliation":[{"name":"Department of Cardiology Northampton General Hospital Northampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8827","authenticated-orcid":false,"given":"C. Anwar A.","family":"Chahal","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Pennsylvania Philadelphia PA"},{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"},{"name":"Department of Cardiology, Barts Heart Centre Barts Health NHS Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-2802","authenticated-orcid":false,"given":"Hiroyuki","family":"Sawatari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"},{"name":"Department of Perioperative and Critical Care Management Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-4454","authenticated-orcid":false,"given":"Mohammed Y.","family":"Khanji","sequence":"additional","affiliation":[{"name":"NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry Queen Mary University of London London United Kingdom"},{"name":"Department of Cardiology St. Bartholomew\u2019s Hospital London United Kingdom"},{"name":"Department of Cardiology Newham University Hospital, Barts Health NHS Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-8654","authenticated-orcid":false,"given":"Hassan","family":"Khan","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-5717","authenticated-orcid":false,"given":"Babken","family":"Asatryan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7314","authenticated-orcid":false,"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Brompton Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-7285","authenticated-orcid":false,"given":"Saurabh","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research Bangalore Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-9883","authenticated-orcid":false,"given":"Rui","family":"Providencia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Barts Heart Centre Barts Health NHS Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-1102","authenticated-orcid":false,"given":"Abhishek","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-8495","authenticated-orcid":false,"given":"Anjali Tiku","family":"Owens","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-4341","authenticated-orcid":false,"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-9275","authenticated-orcid":false,"given":"Deepak","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Pennsylvania Philadelphia PA"},{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"},{"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research Bangalore Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-0344","authenticated-orcid":false,"given":"Heidi","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq249"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783753"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67789-6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.07.006"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.08.022"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S60472"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00047-7"},{"key":"e_1_3_1_10_2","first-page":"123","article-title":"Pregnancy outcomes in Marfan syndrome: a retrospective cohort study","volume":"32","author":"Hassan N","year":"2015","unstructured":"Hassan N, Patenaude V, Oddy L, Abenhaim HA. 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