{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:35:52Z","timestamp":1793730952003,"version":"4.6.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The role of fibroblast growth factor 23 (FGF23) in the development of new\u2010onset heart failure (HF) with reduced (HFrEF) or preserved ejection fraction (HFpEF) in the general population is unknown. Therefore, we set out to investigate associations of C\u2010terminal FGF23 with development of new\u2010onset HF and, more specifically, with HFrEF or HFpEF in a large, prospective, population\u2010based cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 6830 participants (aged 53.8\u00b112.1\u2009years; 49.7% men; estimated glomerular filtration rate, 93.1\u00b115.7\u2009mL\/min per 1.73\u2009m\n              <jats:sup>2<\/jats:sup>\n              ) in the community\u2010based PREVEND (Prevention of Renal and Vascular End\u2010Stage Disease) study who were free of HF at baseline. Cross\u2010sectional multivariable linear regression analysis showed that ferritin (standardized \u03b2, \u22120.24;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and estimated glomerular filtration rate (standardized \u03b2, \u22120.13;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) were the strongest independent correlates of FGF23. Multivariable Cox proportional hazard regression was used to study the association between baseline FGF23 and incident HF, HFrEF (ejection fraction \u226440%) or HFpEF (ejection fraction \u226550%). After median follow\u2010up of 7.4 [IQR 6.9\u20137.9] years, 227 individuals (3.3%) developed new\u2010onset HF, of whom 132 had HFrEF and 88 had HFpEF. A higher FGF23 level was associated with an increased risk of incident HF (fully adjusted hazard ratio, 1.29 [95% CI, 1.06\u20131.57]) and with an increased risk of incident HFrEF (fully adjusted hazard ratio, 1.31 [95% CI, 1.01\u20131.69]). The association between FGF23 and incident HFpEF lost statistical significance after multivariable adjustment (hazard ratio, 1.22 [95% CI, 0.87\u20131.71]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher FGF23 is independently associated with new\u2010onset HFrEF in analyses fully adjusted for cardiovascular risk factors and other potential confounders. The association between FGF23 and incident HFpEF lost statistical significance upon multivariable adjustment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024952","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T12:05:52Z","timestamp":1658750752000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Fibroblast Growth Factor 23 and Risk of New Onset Heart Failure With Preserved or Reduced Ejection Fraction: The PREVEND Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-9485","authenticated-orcid":false,"given":"S. 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L.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-8585","authenticated-orcid":false,"given":"Wiek H.","family":"van Gilst","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Gansevoort","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjan","family":"Navis","sequence":"additional","affiliation":[{"name":"Department of Internal 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