{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:54:36Z","timestamp":1790218476658,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to assess the association between number of pregnancies and long\u2010term progression of cardiac dysfunction, arrhythmias, and event\u2010free survival in women with pathogenic or likely pathogenic variants of gene encoding for Lamin A\/C proteins ( LMNA+).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We retrospectively included consecutive women with LMNA+ and recorded pregnancy data. We collected echocardiographic data, occurrence of atrial fibrillation, atrioventricular block, sustained ventricular arrhythmias, and implantation of cardiac electronic devices (implantable cardioverter defibrillator\/cardiac resynchronization therapy defibrillator). We analyzed retrospectively complications during pregnancy and the peripartum period.<\/jats:p>\n            <jats:p xml:lang=\"en\">\n              We included 89 women with LMNA+ (28% probands, age 41\u00b116\u00a0years), of which 60 had experienced pregnancy. Follow\u2010up time was 5 [interquartile range, 3\u20139] years. We analyzed 452 repeated echocardiographic examinations. Number of pregnancies was not associated with increased long\u2010term risk of atrial fibrillation, atrioventricular block, sustained ventricular arrhythmias, or implantable cardioverter defibrillator\/cardiac resynchronization therapy defibrillator implantation. Women with previous pregnancy and nulliparous women had a similar annual deterioration of left ventricular ejection fraction (\u22120.5\/year versus \u22120.3\/year,\n              <jats:italic>P<\/jats:italic>\n              =0.37) and similar increase of left ventricular end\u2010diastolic diameter (0.1\/year versus 0.2\/year,\n              <jats:italic>P<\/jats:italic>\n              =0.09). Number of pregnancies did not decrease survival free from death, left ventricular assist device, or need for cardiac transplantation. Arrhythmias occurred during 9% of pregnancies. No increase in maternal and fetal complications was observed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In our cohort of women with LMNA+, pregnancy did not seem associated with long\u2010term adverse disease progression or event\u2010free survival. Likewise, women with LMNA+ generally well\u2010tolerated pregnancy, with a small proportion of patients experiencing arrhythmias.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024960","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T11:11:17Z","timestamp":1650280277000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype\u2010Positive"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-856X","authenticated-orcid":false,"given":"Anna I.","family":"Castrini","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo Norway"},{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eystein","family":"Skj\u00f8lsvik","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette E.","family":"Estensen","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-3867","authenticated-orcid":false,"given":"Vibeke M.","family":"Almaas","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-8841","authenticated-orcid":false,"given":"Helge","family":"Skulstad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo Norway"},{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Lyseggen","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-765X","authenticated-orcid":false,"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo Norway"},{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-1117","authenticated-orcid":false,"given":"\u00d8yvind H.","family":"Lie","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kermshlise C. I.","family":"Picard","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Brigham and Women\u2019s Hospital Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-5421","authenticated-orcid":false,"given":"Neal K.","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Brigham and Women\u2019s Hospital Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina H.","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Faculty of Medicine University of Oslo Norway"},{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Norway"},{"name":"Faculty of Medicine Karolinska Institutet AND Cardiovascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.07.038"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.01.013"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01724-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.058"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx596"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.044"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012937"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr040"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12296"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq059"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.078"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.184390"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey061"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa136"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052632"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033083"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.07.001"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.036"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2017.05.010"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy340"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.024960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:54:22Z","timestamp":1715601262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.024960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,4,19]]}},"alternative-id":["10.1161\/JAHA.121.024960"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.024960","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"2021-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e024960"}}