{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:56:30Z","timestamp":1778810190593,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to determine the diagnostic yield of transthoracic (TTE) and transesophageal echocardiography (TEE) in patients with ischemic stroke and transient ischemic attack with established indications for direct oral anticoagulants before the index event.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a retrospective cohort study of consecutive patients with preceding established indications for long\u2010term therapeutic direct oral anticoagulants presenting to a single comprehensive stroke center with ischemic stroke or transient ischemic attack. Choice of echocardiography modality was based on expert recommendations. The primary outcome was a composite of prespecified management\u2010relevant high\u2010risk findings adjudicated by an expert panel, based on TTE and TEE reports according to evidence\u2010based recommendations. Explorative analyses were performed to identify biomarkers associated with the primary outcome. Of 424 patients included (median [interquartile range] age, 78 [70\u201384] years; 175 [41%] women; National Institutes of Health Stroke Scale, 4 [1\u201312]; 67% atrial fibrillation), 292 (69%) underwent echocardiography, while 132 (31%) did not. Modality was TTE in 191 (45%) and TEE in 101 (24%). Median time from index event to echocardiography was 2 (1\u20133) days. TTE identified 26 of 191 (14%) patients with 35 management\u2010relevant pathologies. TEE identified 16 of 101(16%) patients with 20 management\u2010relevant pathologies. Most management\u2010relevant findings represented indicated coronary artery disease and valvular pathologies. In a further 3 of 191 (2%) patients with TTE and 4 of 101 (4%) patients with TEE, other relevant findings were identified. Variables associated with management\u2010relevant high\u2010risk pathologies included more severe stroke, diabetes, and laboratory biomarkers (NT\u2010proBNP [N\u2010terminal pro\u2010B\u2010type natriuretic peptide], C\u2010reactive protein,\n              <jats:sc>d<\/jats:sc>\n              \u2010dimer, and troponin levels).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with established indications for long\u2010term direct oral anticoagulant therapy and stroke who received echocardiography, both TTE and TEE identified a relevant and similar proportion of management\u2010relevant high\u2010risk pathologies and predictive biomarkers could help to guide diagnostic workup in such patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.024989","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:39:47Z","timestamp":1651052387000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Yield of Echocardiography in Ischemic Stroke and Patients With Transient Ischemic Attack With Established Indications for Long\u2010Term Direct Oral Anticoagulant Therapy: A Cross\u2010Sectional Diagnostic Cohort Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-9273","authenticated-orcid":false,"given":"Thomas R.","family":"Meinel","sequence":"first","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Brignoli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Kielkopf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-0770","authenticated-orcid":false,"given":"Leander","family":"Clenin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-7957","authenticated-orcid":false,"given":"Morin","family":"Beyeler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, and University of Bern Bern 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