{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:49:26Z","timestamp":1762325366772,"version":"3.41.2"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In people with peripheral artery disease, post hoc analyses of the LITE (Low Intensity Exercise Intervention in Peripheral Artery Disease) randomized trial were conducted to evaluate the effects of walking exercise at a pace inducing ischemic leg symptoms on walking velocity and the Short Physical Performance Battery, compared with walking exercise without ischemic leg symptoms and compared with a nonexercising control group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants with peripheral artery disease were randomized to: home\u2010based walking exercise that induced ischemic leg symptoms; home\u2010based walking exercise conducted without ischemic leg symptoms; or a nonexercising control group for 12\u00a0months. Outcomes were change of walking velocity over 4\u00a0m and change of the Short Physical Performance Battery (0\u201312, with 12=best) at 6\u2010 and 12\u2010month follow\u2010up. A total of 264 participants (48% women, 61% Black race) were included. Compared with walking exercise without ischemic symptoms, walking exercise that induced ischemic symptoms improved change in usual\u2010paced walking velocity over 4\u00a0m at 6\u2010month (0.056 m\/s [95% CI, 0.019\u20130.094 m\/s];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and 12\u2010month follow\u2010up (0.084 m\/s [95% CI, 0.049\u20130.120 m\/s];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), change in fast\u2010paced of walking velocity over 4\u00a0m at 6\u2010month follow\u2010up (\n              <jats:italic>P<\/jats:italic>\n              =0.03), and change in the Short Physical Performance Battery at 12\u2010month follow\u2010up (0.821 [95% CI, 0.309\u20131.334];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Compared with control, walking exercise at a pace inducing ischemic symptoms improved change in usual\u2010paced walking velocity over 4\u00a0m at 6\u2010month follow\u2010up (0.066 m\/s [95% CI, 0.021\u20130.111 m\/s];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In people with peripheral artery disease, those who walked for exercise at a comfortable pace without ischemic leg symptoms slowed their walking speed during daily life and worsened the Short Physical Performance Battery score, a potentially harmful effect, compared with people who walked for exercise at a pace inducing ischemic leg symptoms. Compared with a control group who did not exercise, home\u2010based walking exercise at a pace inducing ischemic leg symptoms significantly improved change of walking velocity over 4\u00a0m at 6\u2010month follow\u2010up, but this benefit did not persist at 12\u2010month follow\u2010up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">URL: https:\/\/www.clinicaltrials.gov; Unique identifier: NCT02538900.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.025063","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T09:20:40Z","timestamp":1658913640000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-4458","authenticated-orcid":false,"given":"Michael M.","family":"Hammond","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-9868","authenticated-orcid":false,"given":"Bonnie","family":"Spring","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-4649","authenticated-orcid":false,"given":"W. Jack","family":"Rejeski","sequence":"additional","affiliation":[{"name":"Departments of Health and Exercise Science and Geriatric Medicine Wake Forest University Winston Salem NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-2753","authenticated-orcid":false,"given":"Robert","family":"Sufit","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-9661","authenticated-orcid":false,"given":"Michael H.","family":"Criqui","sequence":"additional","affiliation":[{"name":"University of California at San Diego San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Palo Alto 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