{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:57:59Z","timestamp":1780405079825,"version":"3.54.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The objective of this international multicenter study was to investigate both early and late outcomes of cardiac resynchronization therapy (CRT) in patients with a systemic right ventricle (SRV) and to identify predictors for congestive heart failure readmissions and mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This retrospective international multicenter study included 13 centers. The study population comprised 80 adult patients with SRV (48.9% women) with a mean age of 45\u00b114 (range, 18\u201377) years at initiation of CRT. Median follow\u2010up time was 4.1 (25th\u201375th percentile, 1.3\u20138.3) years. Underlying congenital heart disease consisted of congenitally corrected transposition of the great arteries and dextro\u2010transposition of the great arteries in 63 (78.8%) and 17 (21.3%) patients, respectively. CRT resulted in significant improvement in functional class (before CRT: III, 25th\u201375th percentile, II\u2013III; after CRT: II, 25th\u201375th percentile, II\u2013III;\n              <jats:italic>P<\/jats:italic>\n              =0.005) and QRS duration (before CRT: 176\u00b127; after CRT: 150\u00b124\u2009milliseconds;\n              <jats:italic>P<\/jats:italic>\n              =0.003) in patients with pre\u2010CRT ventricular pacing who underwent an upgrade to a CRT device (n=49). These improvements persisted during long\u2010term follow\u2010up with a marginal but significant increase in SRV function (before CRT; 30%, 25th\u201375th percentile, 25\u201335; after CRT: 31%, 25th\u201375th percentile, 21\u201338;\n              <jats:italic>P<\/jats:italic>\n              =0.049). In contrast, no beneficial change in the above\u2010mentioned variables was observed in patients who underwent de novo CRT (n=31). A quarter of all patients were readmitted for heart failure during follow\u2010up, and mortality at latest follow\u2010up was 21.3%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This international experience with CRT in patients with an SRV demonstrated that CRT in selected patients with SRV dysfunction and pacing\u2010induced dyssynchrony yielded consistent improvement in QRS duration and New York Heart Association functional status, with a marginal increase in SRV function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.025121","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:05:29Z","timestamp":1667909129000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Cardiac Resynchronization Therapy for Adult Patients With a Failing Systemic Right Ventricle: A Multicenter Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-4542","authenticated-orcid":false,"given":"Rohit K.","family":"Kharbanda","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Cardiothoracic Surgery Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-9005","authenticated-orcid":false,"given":"Jeremy P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Ahmanson\/UCLA Adult Congenital Heart Disease Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-9330","authenticated-orcid":false,"given":"Michael S.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Galotti","sequence":"additional","affiliation":[{"name":"Ahmanson\/UCLA Adult Congenital Heart Disease Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-1998","authenticated-orcid":false,"given":"Ad J. J. C.","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick J. H. J.","family":"Taverne","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-4568","authenticated-orcid":false,"given":"Malini","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-0152","authenticated-orcid":false,"given":"Christopher J.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-1408","authenticated-orcid":false,"given":"Anne M.","family":"Dubin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-2171","authenticated-orcid":false,"given":"Douglas Y.","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children\u2019s Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-2712","authenticated-orcid":false,"given":"Philip M.","family":"Chang","sequence":"additional","affiliation":[{"name":"Congenital Heart Center University of Florida Health Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N.","family":"Kamp","sequence":"additional","affiliation":[{"name":"The Heart Center Nationwide Children\u2019s Hospital Colombus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-1653","authenticated-orcid":false,"given":"Jens C.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University and Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Aydin","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-1201","authenticated-orcid":false,"given":"Ronn E.","family":"Tanel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, UCSF Benioff Children\u2019s Hospital University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maully J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children\u2019s Hospital of Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-0860","authenticated-orcid":false,"given":"Thomas","family":"Pilcher","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Internal Medicine University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-3098","authenticated-orcid":false,"given":"Reinder","family":"Evertz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-3800","authenticated-orcid":false,"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Electrophysiology Service and Adult Congenital Heart Center, Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9962-8564","authenticated-orcid":false,"given":"Reina B.","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology New York University Langone Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-9555","authenticated-orcid":false,"given":"Richard J.","family":"Czosek","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Cincinnati Children\u2019s Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-1766","authenticated-orcid":false,"given":"Kalyanam","family":"Shivkumar","sequence":"additional","affiliation":[{"name":"Ahmanson\/UCLA Adult Congenital Heart Disease Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-6691","authenticated-orcid":false,"given":"Natasja M. S.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000602"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031544"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000604"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.06.052"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160465"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13568"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw386"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun319"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01274.x"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.096"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.017"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592410"},{"issue":"20","key":"e_1_3_1_15_2","first-page":"30088","article-title":"Permanent conduction system pacing for congenitally corrected transposition of the great arteries: a Pediatric and Congenital Electrophysiology Society (PACES)\/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study","volume":"1547","author":"Moore JP","year":"2020","unstructured":"Moore JP, Gallotti R, Shannon KM, Pilcher T, Vinocur JM, Cano \u00d3, Kean A, Mondesert B, N\u00fcrnberg JH, Schaller RD, et al. Permanent conduction system pacing for congenitally corrected transposition of the great arteries: a Pediatric and Congenital Electrophysiology Society (PACES)\/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study. Heart Rhythm. 2020;S1547\u20135271(20):30088\u201330086. doi: 10.1016\/j.hrthm.2020.01.033","journal-title":"Heart Rhythm"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.000646"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13134"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00074"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-015-0033-5"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu401"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008508"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.062"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13670"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012744"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.11.032"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.025121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:56:10Z","timestamp":1715601370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.025121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":24,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,11,15]]}},"alternative-id":["10.1161\/JAHA.121.025121"],"URL":"https:\/\/doi.org\/10.1161\/jaha.121.025121","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"2021-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e025121"}}