{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:13:32Z","timestamp":1790817212538,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality and cardiovascular risk. However, the prognostic potential of ePWV during long\u2010term follow\u2010up in patients with symptoms of stable angina remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In this study, ePWV was calculated in 25\u00a0066 patients without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean age 63.7\u00b110.5\u00a0years, 58% male) with stable angina pectoris undergoing elective coronary angiography during 2003 to 2016. Multivariable Cox models were used to assess the association with incident all\u2010cause mortality, MI, and stroke. Discrimination was assessed using Harrell\u00b4s C\u2010index. During a median follow\u2010up period of 8.5\u00a0years (interquartile range 5.5\u201311.3\u00a0years), 779 strokes, 1233 MIs, and 4112 deaths were recorded. ePWV was associated with all\u2010cause mortality (hazard ratio [HR] per 1\u00a0m\/s, 1.13; 95% CI, 1.05\u20131.21) and MI (HR per 1\u00a0m\/s 1.23, 95% CI, 1.09\u20131.39) after adjusting for age, systolic blood pressure, body mass index, smoking, estimated glomerular filtration rate, Charlson Comorbidity Index score, antihypertensive treatment, statins, aspirin, and number of diseased coronary arteries. Compared with traditional risk factors, the adjusted model with ePWV was associated with a minor but likely not clinically relevant increase in discrimination for mortality, 76.63% with ePWV versus 76.56% without ePWV,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with stable angina pectoris, ePWV was associated with all\u2010cause mortality and MI beyond traditional risk factors. However, the added prediction of mortality was not improved to a clinically relevant extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.121.025173","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T05:01:28Z","timestamp":1652158888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Estimated Pulse Wave Velocity Is Associated With All\u2010Cause Mortality During 8.5 Years Follow\u2010up in Patients Undergoing Elective Coronary Angiography"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-1596","authenticated-orcid":false,"given":"Esben","family":"Laugesen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Regional Hospital Horsens Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K. 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