{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:59:31Z","timestamp":1790812771770,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD), mitral valve prolapse (MVP), and ventricular arrhythmias. The prevalence of MAD and MVP in patients with IVF in this regard is not well established. We aimed to explore the prevalence of MAD and MVP in a consecutive cohort of patients with IVF compared with matched controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this retrospective, multicenter cohort study, cardiac magnetic resonance images from patients with IVF (ie, negative for ischemia, cardiomyopathy, and channelopathies) and age\u2010 and sex\u2010matched control subjects were analyzed for the presence of MAD (\u22652\u00a0mm) and MVP (&gt;2\u00a0mm). In total, 72 patients (mean age 39\u00b114\u00a0years, 42% women) and 72 control subjects (mean age 41\u00b111\u00a0years, 42% women) were included. MAD in the inferolateral wall was more prevalent in patients with IVF versus healthy controls (7 [11%] versus 1 [1%],\n              <jats:italic>P<\/jats:italic>\n              =0.024). MVP was only seen in patients with IVF and not in controls (5 [7%] versus 0 [0%],\n              <jats:italic>P<\/jats:italic>\n              =0.016). MAD was observed in both patients with (n=4) and without (n=3) MVP.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Inferolateral MAD and MVP were significantly more prevalent in patients with IVF compared with healthy controls. The authors advocate that evaluation of the mitral valve region deserves extra attention in the extensive screening of patients with unexplained cardiac arrest. These findings support further exploration of the pathophysiological mechanisms underlying a subset of IVF that associates with MAD and MVP.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.025364","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T09:16:28Z","timestamp":1659690988000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-9675","authenticated-orcid":false,"given":"Sanne A.","family":"Groeneveld","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1350-8765","authenticated-orcid":false,"given":"Feddo P.","family":"Kirkels","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinder","family":"Evertz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboudumc Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina H.","family":"Haugaa","sequence":"additional","affiliation":[{"name":"ProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter G.","family":"Postema","sequence":"additional","affiliation":[{"name":"Heart Center Department of Clinical and Experimental Cardiology Amsterdam UMC, Location AMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARDHEART)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-3336","authenticated-orcid":false,"given":"Niek H. J.","family":"Prakken","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arco J.","family":"Teske","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-0852","authenticated-orcid":false,"given":"Arthur A. M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Heart Center Department of Clinical and Experimental Cardiology Amsterdam UMC, Location AMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARDHEART)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-9474","authenticated-orcid":false,"given":"Birgitta K.","family":"Velthuis","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-6363","authenticated-orcid":false,"given":"Robin","family":"Nijveldt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboudumc Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0237-7867","authenticated-orcid":false,"given":"Rutger J.","family":"Hassink","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARDHEART)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003817"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz151"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.05.030"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1993.tb01599.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90875-A"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90389-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331977602701209"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.070"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.060"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.029"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602273140902"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801213180315"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90235-0"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14437"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.069"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.05.014"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1412"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004258"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut272"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3283347fdb"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.11.047"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00607-1"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00610-6"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.01.013"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005030"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen174"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.12.006"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300227"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.07.024"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.10.007"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.04.029"},{"key":"e_1_3_1_34_2","first-page":"1","article-title":"Prevalence and extent of mitral annular disjunction in structurally normal hearts: comprehensive 3D analysis using cardiac computed tomography","volume":"00","author":"Toh H","year":"2021","unstructured":"Toh H, Mori S, Izawa YU, Fujita H, Miwa K, Suzuki M, Takahashi YU, Toba T, Watanabe Y, Kono AK, et al. 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