{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:58:07Z","timestamp":1779911887246,"version":"3.53.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prevalence of hypertension subtypes changes with age. However, little is known regarding the age\u2010dependent association of hypertension subtypes with incident heart failure (HF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted an observational cohort study including 2\u00a0612\u00a0570 people (mean age, 44.0\u00a0years; 55.0% men). No participants were taking blood pressure\u2013lowering medications or had a known history of cardiovascular disease. Participants were categorized as aged 20 to 49\u00a0years (n=1\u00a0825\u00a0756), 50 to 59\u00a0years (n=571\u00a0574), or 60 to 75\u00a0years (n=215\u00a0240). We defined stage 1 hypertension as systolic blood pressure (SBP) 130 to 139\u00a0mm\u00a0Hg or diastolic blood pressure (DBP) 80 to 89\u00a0mm\u00a0Hg and stage 2 hypertension as SBP \u2265140\u00a0mm\u00a0Hg or DBP \u226590\u00a0mm\u00a0Hg. Among participants with stage 2 hypertension, isolated diastolic hypertension was defined as SBP &lt;140\u00a0mm\u00a0Hg and DBP \u226590\u00a0mm\u00a0Hg, isolated systolic hypertension as SBP \u2265140\u00a0mm\u00a0Hg and DBP &lt;90\u00a0mm\u00a0Hg, and systolic diastolic hypertension as SBP \u2265140\u00a0mm\u00a0Hg and DBP \u226590\u00a0mm\u00a0Hg. During a mean follow\u2010up of 1205\u00b1934\u00a0days, 43\u00a0415 HF, 4807 myocardial infarction, 45\u00a0365 angina pectoris, 22\u00a0179 stroke, and 10\u00a0420 atrial fibrillation events occurred. Although the incidence of HF and other cardiovascular disease events increased with age, hazard ratios and relative risk reductions of each hypertension subtype for HF decreased with age. An age\u2010dependent relationship between hypertension subtypes and incident HF was similarly observed in both men and women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The contribution of isolated diastolic hypertension, isolated systolic hypertension, and systolic diastolic hypertension to the development of HF and other cardiovascular disease events was attenuated with age, suggesting that preventive efforts for blood pressure control could provide a greater benefit in younger individuals.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.025406","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:42:55Z","timestamp":1651052575000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010Dependent Relationship of Hypertension Subtypes With Incident Heart Failure"],"prefix":"10.1161","volume":"11","author":[{"given":"Yuta","family":"Suzuki","sequence":"first","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"},{"name":"The Department of Advanced Cardiology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-7290","authenticated-orcid":false,"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Advanced Epidemiology NCD Epidemiology Research Center Shiga University of Medical Science Shiga Japan"},{"name":"The Department of Family Medicine and Community Health 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