{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:05:59Z","timestamp":1788973559483,"version":"build-2803163510"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertension and diabetes frequently coexist; however, it has not yet been clarified if the bidirectional longitudinal relationships between arterial stiffness and hypertension are independent of those between arterial stiffness and diabetes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this 16\u2010year prospective observational study, 3960 middle\u2010aged employees of a Japanese company without hypertension\/diabetes at the study baseline underwent annual repeated measurements of blood pressure, serum glycosylated hemoglobin A\n              <jats:sub>1c<\/jats:sub>\n              levels, and brachial\u2010ankle pulse wave velocity. By the end of the study period, 664, 779, 154, and 406 subjects developed hypertension, prehypertension, diabetes, and prediabetes, respectively. Increased brachial\u2010ankle pulse wave velocity at the baseline was associated with a significant odds ratio (per 1 SD increase) for new onset of prehypertension\/hypertension with (2.45\/3.28;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) or without (2.49\/2.76;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) coexisting prediabetes\/diabetes, but not for new onset of prediabetes\/diabetes without coexisting hypertension. Analyses using the latent growth curve model confirmed the bidirectional relationships between brachial\u2010ankle pulse wave velocity and hypertension, but no such relationship was observed between brachial\u2010ankle pulse wave velocity and abnormal glucose metabolism.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In middle\u2010aged employees of a Japanese company, while bidirectional relationships were found to exist between increased arterial stiffness and hypertension, such a relationship was not found between increased arterial stiffness and diabetes. Therefore, it appears that increased arterial stiffness may be associated with the development of hypertension but not with that of diabetes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.121.025924","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T10:46:02Z","timestamp":1656499562000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Bidirectional Longitudinal Relationships Between Arterial Stiffness and Hypertension Are Independent of Those Between Arterial Stiffness and Diabetes: A Large\u2010Scale Prospective Observational Study in Employees of a Japanese Company"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-3702","authenticated-orcid":false,"given":"Hiroki","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Medical University Tokyo 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