{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:24:42Z","timestamp":1792034682792,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Torsade de pointes (TdP) is a potentially fatal cardiac arrhythmia that is often drug induced. Clinical decision support (CDS) may help minimize TdP risk by guiding decision making in patients at risk. CDS has been shown to decrease prescribing of high\u2010risk medications in patients at risk of TdP, but alerts are often ignored. Other risk\u2010management options can potentially be incorporated in TdP risk CDS. Our goal was to evaluate actions clinicians take in response to a CDS advisory that uses a modified Tisdale QT risk score and presents management options that are easily selected (eg, single click).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We implemented an inpatient TdP risk advisory systemwide across a large health care system comprising 30 hospitals. This CDS was programmed to appear when prescribers attempted ordering medications with a known risk of TdP in a patient with a QT risk score \u226512. The CDS displayed patient\u2010specific information and offered relevant management options including canceling offending medications and ordering electrolyte replacement protocols or ECGs. We retrospectively studied the actions clinicians took within the advisory and separated by drug class. During an 8\u2010month period, 7794 TdP risk advisories were issued. Antibiotics were the most frequent trigger of the advisory (n=2578, 33.1%). At least 1 action was taken within the advisory window for 2700 (34.6%) of the advisories. The most frequent action taken was ordering an ECG (n=1584, 20.3%). Incoming medication orders were canceled in 793 (10.2%) of the advisories. The frequency of each action taken varied by drug class (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for all actions).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A modified Tisdale QT risk score\u2013based CDS that offered relevant single\u2010click management options yielded a high action\/response rate. Actions taken by clinicians varied depending on the class of the medication that evoked the TdP risk advisory, but the most frequent was ordering an ECG.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.024338","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T10:39:31Z","timestamp":1654252771000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Clinician Responses to a Clinical Decision Support Advisory for High Risk of Torsades de Pointes"],"prefix":"10.1161","volume":"11","author":[{"given":"Tyler","family":"Gallo","sequence":"first","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine\u2013Phoenix AZ"},{"name":"Department of Pharmacy Practice and Science University of Arizona College of Pharmacy Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-1060","authenticated-orcid":false,"given":"C. William","family":"Heise","sequence":"additional","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine\u2013Phoenix AZ"},{"name":"Department of Medical Toxicology Banner\u2013University Medical Center Phoenix Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-328X","authenticated-orcid":false,"given":"Raymond L.","family":"Woosley","sequence":"additional","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine\u2013Phoenix AZ"},{"name":"Arizona Center for Education and Research on Therapeutics Oro Valley AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-9463","authenticated-orcid":false,"given":"James E.","family":"Tisdale","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy Purdue University Indianapolis IN"},{"name":"Division of Clinical Pharmacology School of Medicine Indiana University Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malinda S.","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Gephart","sequence":"additional","affiliation":[{"name":"Community and Health Systems Science Division College of Nursing University of Arizona Tucson AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-1658","authenticated-orcid":false,"given":"Corneliu C.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"BannerHealth Greeley CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-9394","authenticated-orcid":false,"given":"Daniel C.","family":"Malone","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1888"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_3_2_4_2","unstructured":"Woosley RL Heise CW Gallo T Tate J Woosley D Romero KA. www.CredibleMeds.org QTdrugs List. 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