{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:05:23Z","timestamp":1785769523149,"version":"3.56.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Readmission occurs in 1 out of 3 patients with heart failure (HF). We aimed to study the incidence and prognostic implications of rehospitalizations because of arterial thromboembolism events (ATEs) and venous thromboembolism events (VTEs) after discharge in patients with HF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We identified Medicare beneficiaries who were admitted with a primary diagnosis of HF from 2014 to 2019, with a hospital stay ranging between 3 and10\u00a0days, followed by discharge to home. We calculated incidence of ATEs (myocardial infarction, ischemic stroke, or systemic embolism) and VTEs (deep venous thrombosis and pulmonary embolism) up to 90\u00a0days after discharge. Out of 2\u00a0953\u00a0299 patients admitted with HF during the study period, a total of 585\u00a0353 patients met the inclusion criteria, and 36.6% were readmitted within 90\u00a0days of discharge. The incidence of readmission due ATEs, VTEs, HF, and all other reasons was 3.4%, 0.5%, 13.2%, and 19.5%, respectively. Incidence of thromboembolic events was highest within 14\u00a0days after discharge. Factors associated with ATEs included prior coronary, peripheral, or cerebrovascular disease and for VTEs included malignancy and prior liver or lung disease. ATE\/VTE readmission had a 30\u2010day mortality of 19.9%. After a median follow\u2010up period of 25.6\u00a0months, ATE and VTE readmissions were associated with higher risk of mortality (hazard ratio, 2.76 [95% CI, 2.71\u20132.81] and 2.17 [95% CI, 2.08\u20132.27], respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for both) compared with no readmission on time\u2010dependent Cox regression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">After a HF hospitalization, 3.9% of patients were readmitted with a thromboembolic event that was associated with 2\u2010 to 3\u2010fold greater risk of mortality in follow\u2010up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025342","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T09:04:01Z","timestamp":1652173441000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence and Prognostic Implications of Readmissions Caused by Thrombotic Events After a Heart Failure Hospitalization"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-8394","authenticated-orcid":false,"given":"Pulkit","family":"Chaudhury","sequence":"first","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulino","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madonna","family":"Michael","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-8030","authenticated-orcid":false,"given":"Marwan","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Cardiology Warren Alpert Medical School of Brown UniversityLifespan Cardiovascular Institute Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-5251","authenticated-orcid":false,"given":"G. Jay","family":"Bishop","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Hanna","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-2677","authenticated-orcid":false,"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-4860","authenticated-orcid":false,"given":"Randall C.","family":"Starling","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-461X","authenticated-orcid":false,"given":"Alex C.","family":"Spyropoulos","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research and The Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Hempstead NY"},{"name":"Department of Medicine Northwell Health at Lenox Hill Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-9797","authenticated-orcid":false,"given":"Milind","family":"Desai","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-2517","authenticated-orcid":false,"given":"Amgad","family":"Mentias","sequence":"additional","affiliation":[{"name":"Heart, Thoracic and Vascular InstituteCleveland Clinic Foundation Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004873"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.038"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.008335"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000794"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014949"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2015.09.004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.296"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420020066008"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.1002"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53641-0"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022157"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4537"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700518"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.071"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006015"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021579"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1198\/000313005X70371"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780030106"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1974.10480131"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.25.3060"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00268-9"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.963"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311660"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122072"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313137"},{"key":"e_1_3_1_29_2","article-title":"State\u2010of\u2010the\u2010art\u2010mini review: Dual pathway inhibition to reduce arterial and venous thromboembolism","author":"Goldin M","year":"2022","unstructured":"Goldin M, Koulas I, Weitz JI, Spyropoulos A. 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