{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:43:46Z","timestamp":1753883026166,"version":"3.41.2"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Sarcoidosis is an inflammatory, noncaseating, granulomatous disorder of unknown cause that can affect any body system and is associated with cardiovascular disease including sudden cardiac death (SCD). Cardiac involvement in sarcoidosis is associated with higher risk of SCD, but the SCD risk in the general sarcoidosis population is unknown. We aimed to determine the risk of SCD in people with sarcoidosis versus the matched general population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A population\u2010based cohort of sarcoidosis and age\u2010 and sex\u2010matched comparators from January 1, 1976 to December 31, 2013 was used; presence of other comorbidities in the comparator group was not an exclusion criterion. Mortality, including time, place, and cause of death were measured and manually adjudicated for SCD events. Incidence rates are reported per 100\u2009000 person\u2010years, and Cox models were used for group comparisons. Of the 345 incident cases of sarcoidosis (171 men; 50%) there were 58 reported deaths; 10 were definite\/probable SCD versus 57 all\u2010cause and 9 SCDs in comparators. Median follow\u2010up was 12.9\u2009years (interquartile range, 6.0\u201323.4\u2009years) . Incidence rate of SCD in sarcoidosis was 192 (95% CI, 92\u2013352) versus 155 (95% CI, 71\u2013294) in comparators (hazard ratio [HR], 1.28 (95% CI, 0.52\u20133.17). Nocturnal deaths were more frequent in sarcoidosis 57 (95% CI, 12\u2013168) versus 17 (95% CI, 0.4\u201395) (HR, 3.76 [95% CI, 0.39\u201336.47]). No significant differences were detected between the groups by sex, age, calendar year of diagnosis, or disease duration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In a population\u2010based cohort of patients with sarcoidosis, the risk for SCD compared with matched comparators was not increased. There were more nocturnal deaths among patients with sarcoidosis, yet this was statistically insignificant.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025479","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T09:16:21Z","timestamp":1659690981000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Sudden Death in a General Unbiased Epidemiological Cohort of Sarcoidosis"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8827","authenticated-orcid":false,"given":"C. Anwar A.","family":"Chahal","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Mayo Clinic Rochester MN"},{"name":"Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic Rochester MN"},{"name":"Department of Cardiology Mayo Clinic Rochester MN"},{"name":"Department of Cardiology WellSpan Health York PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-1119","authenticated-orcid":false,"given":"Peter A.","family":"Brady","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Mayo Clinic Rochester MN"},{"name":"Division of Heart Rhythm Services, Department of Cardiology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-3313","authenticated-orcid":false,"suffix":"Jr","given":"Leslie T.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Jacksonville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-1150","authenticated-orcid":false,"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Mayo Clinic Rochester MN"},{"name":"Department of Cardiology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-4341","authenticated-orcid":false,"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Mayo Clinic Rochester MN"},{"name":"Department of Cardiology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research Mayo Clinic College of Medicine and Science Rochester MN"},{"name":"Division of Rheumatology, Department of Internal Medicine Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research Mayo Clinic College of Medicine and Science Rochester MN"},{"name":"Division of Rheumatology, Department of Internal Medicine Mayo Clinic College of Medicine and Science Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patompong","family":"Ungprasert","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Mayo Clinic College of Medicine and Science Rochester MN"},{"name":"Department of Rheumatologic and Immunologic Disease Cleveland Clinic Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603087"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.043"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-015-9978-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.10.024"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d02.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180199"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006273"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075307"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0413"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.130.1.29"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062836"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00457-2016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.03.028"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80047-2"},{"key":"e_1_3_2_20_2","first-page":"75","article-title":"Defining organ involvement in sarcoidosis: the access proposed instrument. Access research group. A case control etiologic study of sarcoidosis","volume":"16","author":"Judson MA","year":"1999","unstructured":"Judson MA, Baughman RP, Teirstein AS, Terrin ML, Yeager H Jr. Defining organ involvement in sarcoidosis: the access proposed instrument. Access research group. A case control etiologic study of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999;16:75\u201386.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2784"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2104046"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.025479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:25:28Z","timestamp":1715599528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.025479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":21,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1161\/JAHA.122.025479"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.025479","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e025479"}}