{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:30:52Z","timestamp":1793406652637,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Whether visit\u2010to\u2010visit systolic blood pressure (SBP) variability can predict major adverse cardiovascular events (MACE) in patients with chronic kidney disease is unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We investigated the relationship between SDs of visit\u2010to\u2010visit SBP variability during the first year of enrollment and MACE among 1575 participants from KNOW\u2010CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into 3 groups according to tertiles of visit\u2010to\u2010visit SBP variability (SD). The study end point was MACE, defined as a composite of nonfatal myocardial infarction, unstable angina, revascularization, nonfatal stroke, hospitalization for heart failure, or cardiac death. During 6748 patient\u2010years of follow\u2010up (median, 4.2\u00a0years), MACE occurred in 64 participants (4.1%). Compared with the lowest tertile of visit\u2010to\u2010visit SBP variability (SD), the hazard ratios (HRs) for the middle and the highest tertile were 1.64 (95% CI, 0.80\u20133.36) and 2.23 (95% CI, 1.12\u20134.44), respectively, in a multivariable cause\u2010specific hazard model. In addition, the HR associated with each 5\u2010mm\u00a0Hg increase in visit\u2010to\u2010visit SBP variability (SD) was 1.21 (95% CI, 1.01\u20131.45). This association was consistent in sensitivity analyses with 2 additional definitions of SBP variability determined by the coefficient of variation and variation independent of the mean. The corresponding HRs for the middle and highest tertiles were 2.11 (95% CI, 1.03\u20134.35) and 2.28 (95% CI, 1.12\u20134.63), respectively, in the analysis with the coefficient of variation and 1.76 (95% CI, 0.87\u20133.57) and 2.04 (95% CI, 1.03\u20134.03), respectively, with the variation independent of the mean.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher visit\u2010to\u2010visit SBP variability is associated with an increased risk of MACE in patients with chronic kidney disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01630486.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025513","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T10:38:43Z","timestamp":1654252723000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW\u2010CKD"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-5745","authenticated-orcid":false,"given":"Cheol Ho","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-452X","authenticated-orcid":false,"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-0928","authenticated-orcid":false,"given":"Young Su","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Tak","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-6379","authenticated-orcid":false,"given":"Tae Ik","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Health Insurance Service Medical CenterIlsan Hospital Goyangshi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-4507","authenticated-orcid":false,"given":"Tae\u2010Hyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5002-9707","authenticated-orcid":false,"given":"Sue Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Wan","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnamsi Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wookyung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gil Medical CenterGachon University Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-1289","authenticated-orcid":false,"given":"Yong\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St Mary\u2019s HospitalCollege of MedicineThe Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook\u2010Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University HospitalKidney Research Institute Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-5635","authenticated-orcid":false,"given":"Seung Hyeok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on the behalf of the KNOW\u2010CKD (Korean 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