{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:48:39Z","timestamp":1781326119720,"version":"3.54.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short\u2010term well\u2010controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallel\u2010arm trial designed to test whether consuming 1 large avocado per day for 6\u2009months in a diverse group of free\u2010living individuals (N=1008) with an elevated waist circumference compared with a habitual diet would decrease visceral adiposity as measured by magnetic resonance imaging. Secondary and additional end points related to risk factors associated with cardiometabolic disorders were assessed. The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups (estimated mean difference (0.017\u2009L [\u22120.024\u2009L, 0.058\u2009L],\n              <jats:italic>P<\/jats:italic>\n              =0.405). No significant group differences were observed for the secondary outcomes of hepatic fat fraction, hsCRP (high\u2010sensitivity C\u2010reactive protein), and components of the metabolic syndrome. Of the additional outcome measures, modest but nominally significant reductions in total and low\u2010density lipoprotein cholesterol were observed in the Avocado Supplemented compared with the Habitual Diet Group. Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very low\u2010density lipoprotein concentrations, and total cholesterol:high\u2010density lipoprotein cholesterol ratio) were similar between the 2 groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Addition of 1 avocado per day to the habitual diet for 6\u2009months in free\u2010living individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardiometabolic disorders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03528031.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025657","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:18:11Z","timestamp":1657019891000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-9478","authenticated-orcid":false,"given":"Alice H.","family":"Lichtenstein","sequence":"first","affiliation":[{"name":"JM USDA Human Nutrition Center on Aging, Tufts University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny 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