{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:31:40Z","timestamp":1788420700850,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is significant regional or institutional variation in the use of thrombus aspiration (TA) in patients undergoing percutaneous coronary intervention (PCI). We investigated the temporal trend in TA use and its association with clinical outcomes in acute coronary syndrome using the nationwide J\u2010PCI (Japanese PCI) registry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Between 2016 and 2018, patients with acute coronary syndrome undergoing PCI (n=282\u2009606; median age, 71.0\u2009years; interquartile range, 62.0\u201379.0\u2009years; women, 24.7%) at 1124 hospitals were stratified on the basis of whether TA was performed (TA and non\u2010TA). The patients were subdivided according to clinical presentation (ST\u2010segment\u2013elevation myocardial infarction, non\u2013ST\u2010segment\u2013elevation myocardial infarction, and unstable angina). Successful PCI, defined as the achievement of TIMI (Thrombolysis in Myocardial Infarction) 3 flow, and in\u2010hospital mortality were assessed. During the study period, 83\u2009422 patients (29.5%) underwent TA (52.9%, 23.5%, and 5.2% for ST\u2010segment\u2013elevation myocardial infarction, non\u2013ST\u2010segment\u2013elevation myocardial infarction, and unstable angina, respectively), and the TA implementation rate remained relatively stable throughout. Patients treated with TA had higher rate of successful PCI than non\u2010TA (98.7% versus 97.8%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). TA was not associated with in\u2010hospital death among patients with ST\u2010segment\u2013elevation myocardial infarction (adjusted odds ratio [aOR], 1.02 [95% CI, 0.94\u20131.12]). However, TA use was associated with higher rates of in\u2010hospital death in patients with non\u2013ST\u2010segment\u2013elevation myocardial infarction ( aOR, 1.51 [95% CI, 1.23\u20131.86]) or unstable angina ( aOR, 1.95 [95% CI, 1.37\u20132.79]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In our retrospective analysis of the nationwide PCI registry, TA use was associated with a higher achievement of successful PCI without impairing in\u2010hospital mortality among patients with ST\u2010segment\u2013elevation myocardial infarction. Nevertheless, its use should be cautioned in less\u2010established indications (eg, non\u2013ST\u2010segment\u2013elevation myocardial infarction and unstable angina).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025728","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:37:52Z","timestamp":1660124272000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Use of Thrombus Aspiration for Patients With Acute Coronary Syndrome: Insights From the Nationwide J\u2010PCI Registry"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-2083","authenticated-orcid":false,"given":"Taku","family":"Inohara","sequence":"first","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-2972","authenticated-orcid":false,"given":"Shun","family":"Kohsaka","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-9186","authenticated-orcid":false,"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Iida","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-7538","authenticated-orcid":false,"given":"Toshiro","family":"Shinke","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakakura","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-0123","authenticated-orcid":false,"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Amano","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-4324","authenticated-orcid":false,"given":"Yuji","family":"Ikari","sequence":"additional","affiliation":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics Tokyo 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