{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:44:05Z","timestamp":1753883045427,"version":"3.41.2"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are limited data on risk of arrhythmias among patients with lymphoproliferative disorders. We designed this study to determine the risk of atrial and ventricular arrhythmia during treatment of lymphoma in a real\u2010world setting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study population comprised 2064 patients included in the University of Rochester Medical Center Lymphoma Database from January 2013 to August 2019. Cardiac arrhythmias\u2014atrial fibrillation\/flutter, supraventricular tachycardia, ventricular arrhythmia, and bradyarrhythmia\u2014were identified using\n              <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic>\n              (\n              <jats:italic>ICD\u201010<\/jats:italic>\n              ) codes. Multivariate Cox regression analysis was used to assess the risk of arrhythmic events with treatments categorized as Bruton tyrosine kinase inhibitor (BTKi), mainly ibrutinib\/non\u2010BTKi treatment versus no treatment. Median age was 64 (54\u201372) years, and 42% were women. The overall rate of any arrhythmia at 5\u2009years following the initiation of BTKi was (61%) compared with (18%) without treatment. Atrial fibrillation\/flutter was the most common type of arrhythmia accounting for 41%. Multivariate analysis showed that BTKi treatment was associated with a 4.3\u2010fold (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) increased risk for arrhythmic event (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with no treatment, whereas non\u2010BTKi treatment was associated with a 2\u2010fold (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) risk increase. Among subgroups, patients without a history of prior arrhythmia exhibited a pronounced increase in the risk for the development of arrhythmogenic cardiotoxicity (3.2\u2010fold;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study identifies a high burden of arrhythmic events after initiation of treatment, which is most pronounced among patients treated with the BTKi ibrutinib. Patients undergoing treatments for lymphoma may benefit from prospective focused cardiovascular monitoring prior, during, and after treatment regardless of arrhythmia history.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025786","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T11:40:40Z","timestamp":1678362040000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Arrhythmogenic Cardiotoxicity Associated With Contemporary Treatments of Lymphoproliferative Disorders"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-2442","authenticated-orcid":false,"given":"Saadia","family":"Sherazi","sequence":"first","affiliation":[{"name":"Division of Cardiology Clinical Cardiovascular Research Center University of Rochester School of Medicine and Dentistry Rochester 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NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-7052","authenticated-orcid":false,"given":"Neelima","family":"Vidula","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9384","authenticated-orcid":false,"given":"Mehmet K.","family":"Aktas","sequence":"additional","affiliation":[{"name":"Division of Cardiology Clinical Cardiovascular Research Center University of Rochester School of Medicine and Dentistry Rochester NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-3313","authenticated-orcid":false,"given":"Clive S.","family":"Zent","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Wilmot Cancer Institute University of Rochester School of Medicine and Dentistry Rochester 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