{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:22:51Z","timestamp":1769581371541,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Current recommendations for delivery timing of pregnant persons with congenital heart disease (CHD) are based on expert opinion. Justification for early\u2010term birth is based on the theoretical concern of increased cardiovascular stress. The objective was to evaluate whether early\u2010term birth with maternal CHD is associated with lower adverse maternal or neonatal outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is a retrospective cohort study of pregnant persons with CHD who delivered a singleton after 37 0\/7\u2009weeks gestation at a quaternary care center with a multidisciplinary cardio\u2010obstetrics care team between 2013 and 2021. Patients were categorized as early\u2010term (37 0\/7 to 38 6\/7\u2009weeks) or full\u2010term (\u226539 0\/7) births and compared. Multivariable logistic regression was conducted to calculate the adjusted odds ratio for the primary outcomes. The primary outcomes were composite adverse cardiovascular, maternal obstetric, and adverse neonatal outcome. Of 110 pregnancies delivering at term, 55 delivered early\u2010term and 55 delivered full\u2010term. Development of adverse cardiovascular and maternal obstetric outcome was not significantly different by delivery timing. The rate of composite adverse neonatal outcomes was significantly higher in early\u2010term births (36% versus 5%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). After adjusting for confounding variables, early\u2010term birth remained associated with a significantly increased risk of adverse neonatal outcomes (adjusted odds ratio 11.55 [95% CI, 2.59\u201351.58]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Early\u2010term birth for pregnancies with maternal CHD was associated with an increased risk of adverse neonatal outcomes, without an accompanying decreased rate in adverse cardiovascular or obstetric outcomes. In the absence of maternal or fetal indications for early birth, induction of labor before 39\u2009weeks for pregnancies with maternal CHD should be reserved for routine obstetrical indications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025791","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T10:46:06Z","timestamp":1660041966000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Delivery Timing and Associated Outcomes in Pregnancies With Maternal Congenital Heart Disease at Term"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-5562","authenticated-orcid":false,"given":"Thalia","family":"Mok","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Small","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine New York University Langone Health New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Canobbio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Ahmanson\/UCLA Adult Congenital Heart Disease Center University of California Los Angeles CA"},{"name":"UCLA School of Nursing University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha D.","family":"Tandel","sequence":"additional","affiliation":[{"name":"Department of Urology University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Urology University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-8993","authenticated-orcid":false,"given":"Gentian","family":"Lluri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Ahmanson\/UCLA Adult Congenital Heart Disease Center University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-9099","authenticated-orcid":false,"given":"Leigh","family":"Reardon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Ahmanson\/UCLA Adult Congenital Heart Disease Center University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0209-9505","authenticated-orcid":false,"given":"Jamil","family":"Aboulhosn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Ahmanson\/UCLA Adult Congenital Heart Disease Center University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-4629","authenticated-orcid":false,"given":"Jeannette","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Ahmanson\/UCLA Adult Congenital Heart Disease Center University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-7022","authenticated-orcid":false,"given":"Yalda","family":"Afshar","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000458"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000602"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.027"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.076"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3001.093437"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.589655"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820cab69"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0283"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.3667"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000772"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800566"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003762"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305597"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq200"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr218"},{"key":"e_1_3_1_17_2","volume-title":"Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels","author":"Dolgin M","year":"1994","unstructured":"Dolgin M. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Little, Brown and Company; 1994.","edition":"9"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192065"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002351"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003076"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803267"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1015"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.068"},{"key":"e_1_3_1_25_2","first-page":"e29","article-title":"Medically indicated late\u2010preterm and early\u2010term deliveries. ACOG Committee opinion no. 818. American College of Obstetricians and Gynecologists","volume":"137","year":"2021","unstructured":"Medically indicated late\u2010preterm and early\u2010term deliveries. ACOG Committee opinion no. 818. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2021;137:e29\u2013e33. doi: 10.1097\/AOG.0000000000004245","journal-title":"Obstet Gynecol"},{"key":"e_1_3_1_26_2","article-title":"Timing of delivery in women with cardiac disease","author":"Rouse CE","year":"2020","unstructured":"Rouse CE, Easter SR, Duarte VE, Draakely S, Wu FM, Valente AM, Economy KE. Timing of delivery in women with cardiac disease. Am J Perinatol. 2020. [Epub ahead of print]. doi: 10.1055\/s\u20100040\u20101721716","journal-title":"Am J Perinatol"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.08.037"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.025791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:25:18Z","timestamp":1715599518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.025791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":26,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1161\/JAHA.122.025791"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.025791","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e025791"}}