{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:36:33Z","timestamp":1778614593199,"version":"3.51.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The prognostic role of BNP (B\u2010type natriuretic peptide) in patients with cardiac sarcoidosis without evident heart failure is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This is a post hoc analysis of ILLUMINATE\u2010CS (Illustration of the Management and Prognosis of Japanese Patients With Cardiac Sarcoidosis), a multicenter, retrospective, and observational study that evaluated the clinical characteristics and prognosis of cardiac sarcoidosis. We analyzed patients with cardiac sarcoidosis without evident heart failure at the time of diagnosis. The association between baseline BNP levels and prognosis was investigated. The primary end point was the combined end point of all\u2010cause death, heart failure hospitalization, and fatal ventricular arrhythmia. In total, 238 patients (61.0\u00b111.1\u2009years, 37% men) were analyzed, and 61 primary end points were observed during a median follow\u2010up period of 3.0 (interquartile range, 1.7\u20135.8) years. Patients with high BNP (BNP above the median value of BNP) were older and had a lower renal function and left ventricular ejection fraction than those with low BNP values. Kaplan\u2013Meier curve analysis indicated that high BNP levels were significantly associated with a high incidence of primary end points (log\u2010rank\n              <jats:italic>P<\/jats:italic>\n              =0.004), and this association was retained even in multivariable Cox regression (hazard ratio, 2.06 [95% CI, 1.19\u20133.55];\n              <jats:italic>P<\/jats:italic>\n              =0.010). Log\u2010transformed BNP as a continuous variable was associated with the primary end point (hazard ratio, 2.12 [95% CI, 1.31\u20133.43];\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">High baseline BNP level was an independent predictor of future adverse events in patients with cardiac sarcoidosis without heart failure at the time of diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/english\/\">https:\/\/www.umin.ac.jp\/english\/<\/jats:ext-link>\n              ; Unique Identifier: UMIN\u2010CTR: UMIN000034974.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025803","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:38:48Z","timestamp":1671017928000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["The Prognostic Value of B\u2010Type Natriuretic Peptide in Patients With Cardiac Sarcoidosis Without Heart Failure: Insights From ILLUMINATE\u2010CS"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-1750","authenticated-orcid":false,"given":"Shota","family":"Miyakuni","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Cardiology Kameda Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-3500","authenticated-orcid":false,"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-8525","authenticated-orcid":false,"given":"Yuya","family":"Matsue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kameda Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-4589","authenticated-orcid":false,"given":"Taishi","family":"Dotare","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Sunayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-7667","authenticated-orcid":false,"given":"Takeru","family":"Nabeta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kitasato University School of Medicine Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-951X","authenticated-orcid":false,"given":"Yoshihisa","family":"Naruse","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-5865","authenticated-orcid":false,"given":"Takeshi","family":"Kitai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsunori","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5076-2052","authenticated-orcid":false,"given":"Takahiro","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-0443","authenticated-orcid":false,"given":"Yuichi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Geriatrics, Kochi Medical School Kochi University Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kameda Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-6151","authenticated-orcid":false,"given":"Tohru","family":"Minamino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Japan Agency for Medical Research and Development\u2010Core Research for Evolutionary Medical Science and Technology (AMED\u2010CREST) Japan Agency for Medical Research and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2101555"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-316442"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115146"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h910"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.11.085"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-014-9439-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.028"},{"key":"e_1_3_1_9_2","first-page":"27","article-title":"Significance of plasma NT\u2010proBNP levels as a biomarker in the assessment of cardiac involvement and pulmonary hypertension in patients with sarcoidosis","volume":"27","author":"Handa T","year":"2010","unstructured":"Handa T, Nagai S, Ueda S, Chin K, Ito Y, Watanabe K, Tanizawa K, Tamaya M, Mishima M, Izumi T. Significance of plasma NT\u2010proBNP levels as a biomarker in the assessment of cardiac involvement and pulmonary hypertension in patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2010;27:27\u201335.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1609"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac323"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0508"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.043"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197112232852601"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2018"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw302"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005927"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016642.15031.34"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01672-2"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1746"},{"key":"e_1_3_1_22_2","first-page":"1","article-title":"Testing for BNP and NT\u2010proBNP in the diagnosis and prognosis of heart failure","volume":"142","author":"Balion C","year":"2006","unstructured":"Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M, McKelvie R, Booker L, Fagbemi J, Reichert S, et al. Testing for BNP and NT\u2010proBNP in the diagnosis and prognosis of heart failure. Evid Rep Technol Assess (Full Rep). 2006;142:1\u2010147.","journal-title":"Evid Rep Technol Assess (Full Rep)"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-695"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13614"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.04.016"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1217"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019415"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.103010"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-89"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.36141\/svdld.v36i4.8606"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0796fje"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.071423"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021183"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000144"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2020.06.028"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e3182531cf7"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01978-6"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.083"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.865"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.025803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:40:30Z","timestamp":1715600430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.025803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2022,12,20]]}},"alternative-id":["10.1161\/JAHA.122.025803"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.025803","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e025803"}}