{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:35:34Z","timestamp":1780479334887,"version":"3.54.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,10,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiovascular complications from COVID\u201019 contribute to its high morbidity and mortality. The effect of COVID\u201019 infection on the coronary vasculature is not known. The objective of this study was to investigate the prevalence of coronary vasomotor dysfunction identified by coronary flow reserve from cardiac positron emission tomography in patients with previous COVID\u201019 infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              All patients who had polymerase chain reaction\u2013confirmed SARS\u2010CoV\u20102 infection referred for myocardial stress perfusion positron emission tomography imaging at Brigham and Women's Hospital from April 2020 to July 2021 were compared with a matched control group without prior SARS\u2010CoV\u20102 infection imaged in the same period. The main outcome was the prevalence of coronary vasomotor dysfunction. Myocardial perfusion and myocardial blood flow reserve were quantified using N13\u2010ammonia positron emission tomography imaging. Thirty\u2010four patients with prior COVID\u201019 were identified and compared with 103 matched controls. The median time from polymerase chain reaction\u2013confirmed SARS\u2010CoV\u20102 to cardiac positron emission tomography was 4.6 months (interquartile range,1.2\u20135.6 months). There were 16 out of 34 (47%) patients previously hospitalized for COVID\u201019 infection. Baseline cardiac risk factors were common, and 18 (53%) patients in the COVID\u201019 group had abnormal myocardial perfusion. Myocardial blood flow reserve was abnormal (&lt;2) in 44.0% of the patients with COVID\u201019 compared with 11.7% of matched controls (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The mean myocardial blood flow reserve was 19.4% lower in patients with COVID\u201019 compared with control patients (2.00\u00b10.45 versus 2.48\u00b10.47,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Myocardial blood flow reserve was impaired in patients with prior COVID\u201019 infection compared with cardiovascular risk factor\u2013matched controls, suggesting a relationship between SARS\u2010CoV\u20102 infection and coronary vascular health. These data highlight the need to assess long\u2010term consequences of COVID\u201019 on vascular health in future prospective studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.025844","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:23:40Z","timestamp":1666009420000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Prior SARS\u2010CoV\u20102 Infection Is Associated With Coronary Vasomotor Dysfunction as Assessed by Coronary Flow Reserve From Cardiac Positron Emission Tomography"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2091","authenticated-orcid":false,"given":"Brittany","family":"Weber","sequence":"first","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7893-8136","authenticated-orcid":false,"given":"Sean","family":"Parks","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-8078","authenticated-orcid":false,"given":"Daniel M.","family":"Huck","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-2881","authenticated-orcid":false,"given":"Andy","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camden","family":"Bay","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-639X","authenticated-orcid":false,"given":"Jenifer M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston 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Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Bibbo","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-3781","authenticated-orcid":false,"given":"Viviany","family":"Taqueti","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-1185","authenticated-orcid":false,"given":"Sharmila","family":"Dorbala","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Program, Departments of Medicine and Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Cardiovascular Division, Department of Medicine Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann 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of long covid symptoms after covid\u201019 vaccination: community based cohort study","volume":"377","author":"Ayoubkhani D","year":"2022","unstructured":"Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, Khunti K, Alwan NA, Walker AS. Trajectory of long covid symptoms after covid\u201019 vaccination: community based cohort study. BMJ. 2022;377:e069676.","journal-title":"BMJ"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29521-z"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.025844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:42:37Z","timestamp":1715600557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.025844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":12,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,10,18]]}},"alternative-id":["10.1161\/JAHA.122.025844"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.025844","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"2022-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e025844"}}