{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:40:37Z","timestamp":1790851237875,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with congenital heart disease (CHD) are at risk for the development of low cardiac output and other physiologic derangements, which could be detected early through continuous stroke volume (SV) measurement. Unfortunately, existing SV measurement methods are limited in the clinic because of their invasiveness (eg, thermodilution), location (eg, cardiac magnetic resonance imaging), or unreliability (eg, bioimpedance). Multimodal wearable sensing, leveraging the seismocardiogram, a sternal vibration signal associated with cardiomechanical activity, offers a means to monitoring SV conveniently, affordably, and continuously. However, it has not been evaluated in a population with significant anatomical and physiological differences (ie, children with CHD) or compared against a true gold standard (ie, cardiac magnetic resonance). Here, we present the feasibility of wearable estimation of SV in a diverse CHD population (N=45 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We used our chest\u2010worn wearable biosensor to measure baseline ECG and seismocardiogram signals from patients with CHD before and after their routine cardiovascular magnetic resonance imaging, and derived features from the measured signals, predominantly systolic time intervals, to estimate SV using ridge regression. Wearable signal features achieved acceptable SV estimation (28% error with respect to cardiovascular magnetic resonance imaging) in a held\u2010out test set, per cardiac output measurement guidelines, with a root\u2010mean\u2010square error of 11.48\u2009mL and\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      of 0.76. Additionally, we observed that using a combination of electrical and cardiomechanical features surpassed the performance of either modality alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">A convenient wearable biosensor that estimates SV enables remote monitoring of cardiac function and may potentially help identify decompensation in patients with CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.026067","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T05:44:14Z","timestamp":1663134254000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Wearable Seismocardiography\u2010Based Assessment of Stroke Volume in Congenital Heart Disease"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-0421","authenticated-orcid":false,"given":"Venu G.","family":"Ganti","sequence":"first","affiliation":[{"name":"Bioengineering Graduate Program Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-2823","authenticated-orcid":false,"given":"Asim H.","family":"Gazi","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-8478","authenticated-orcid":false,"given":"Sungtae","family":"An","sequence":"additional","affiliation":[{"name":"School of Interactive Computing Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-9687","authenticated-orcid":false,"given":"Adith V.","family":"Srivatsa","sequence":"additional","affiliation":[{"name":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2549-2032","authenticated-orcid":false,"given":"Brandi N.","family":"Nevius","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-6681","authenticated-orcid":false,"given":"Christopher J.","family":"Nichols","sequence":"additional","affiliation":[{"name":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-5187","authenticated-orcid":false,"given":"Andrew M.","family":"Carek","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, McCormick School of Engineering Northwestern University Evanston IL"},{"name":"Department of Anesthesiology, Feinberg School of Medicine Northwestern University Evanston IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-2815","authenticated-orcid":false,"given":"Munes","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1607-8537","authenticated-orcid":false,"given":"Mubeena","family":"Abdulkarim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-6566","authenticated-orcid":false,"given":"F. Gerald","family":"Greil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-9220","authenticated-orcid":false,"given":"Mozziyar","family":"Etemadi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, McCormick School of Engineering Northwestern University Evanston IL"},{"name":"Department of Anesthesiology, Feinberg School of Medicine Northwestern University Evanston IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-1794","authenticated-orcid":false,"given":"Omer T.","family":"Inan","sequence":"additional","affiliation":[{"name":"Bioengineering Graduate Program Georgia Institute of Technology Atlanta GA"},{"name":"School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-8801","authenticated-orcid":false,"given":"Animesh","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Medical Center Dallas TX"},{"name":"Cleveland Clinic Children\u2019s Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3435"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.10.073"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008775"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.964965"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.071"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304958"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540110043030"},{"key":"e_1_3_2_10_2","first-page":"104","article-title":"Non\u2010invasive cardiac output monitoring techniques in the ICU","volume":"26","author":"Kerstens MK","year":"2018","unstructured":"Kerstens MK, Wijnberge M, Geerts BF, Vlaar AP, Veelo DP. Non\u2010invasive cardiac output monitoring techniques in the ICU. Neth J Crit Care. 2018;26:104\u2013110. Available at. http:\/\/www.deltexmedical.com\/downloads\/clinicaleducationguides","journal-title":"Neth J Crit Care"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02381-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu447"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2020.3032938"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004313"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13522"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2009.5334444"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318246c32c"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-51"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.016"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2020.3021532"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1145\/3130905"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.25.4.425"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009982611386"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181ee3130"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(61)90403-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199202000-00005"},{"key":"e_1_3_2_27_2","unstructured":"Lewis RP Rittgers SE Forester WF Boudoulas H. Reviews of contemporary laboratory methods. A Critical Review of the Systolic Time Intervals. Available at: http:\/\/ahajournals.org. Accessed August 5 2021."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02344724"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4867-1.00008-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2021.1968089"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/S19132922"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043392"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","unstructured":"Kim S Leonhardt S Zimmermann N Kranen P Kensche D M\u00fcller E Quix C. Influence of contact pressure and moisture on the signal quality of a newly developed textile ECG sensor shirt. Proceedings of the 5th International Workshop on Wearable and Implantable Body Sensor Networks (BSN 2008) in conjunction with the 5th International Summer School and Symposium on Medical Devices and Biosensors (ISSS\u2010MDBS 2008). 2008; 256\u2013259. doi: 10.1109\/ISSMDBS.2008.4575068","DOI":"10.1109\/ISSMDBS.2008.4575068"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900290"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2010.2044185"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4200"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:09:44Z","timestamp":1715584184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,20]]}},"alternative-id":["10.1161\/JAHA.122.026067"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026067","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2022-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026067"}}