{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:12:55Z","timestamp":1791879175632,"version":"4.3.4"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite being the most frequent complication following transcatheter aortic valve replacement (TAVR), optimal management of left bundle\u2010branch block (LBBB) remains unknown. Electrophysiology study has been proposed for risk stratification. However, the optimal timing of electrophysiology study remains unknown. We aimed to investigate the temporal dynamics of atrioventricular conduction in patients with new\u2010onset LBBB after TAVR by performing serial electrophysiology study and to deduce a treatment strategy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We assessed consecutive patients undergoing TAVR via His\u2010ventricular interval measurement prevalve and postvalve deployment and the day after TAVR. Infranodal conduction delay was defined as a His\u2010ventricular interval &gt;55\u2009milliseconds. Among 107 patients undergoing TAVR, 53 patients (50%) experienced new\u2010onset LBBB postvalve deployment and infranodal conduction delay was noted in 24 of 53 patients intraprocedurally (45%). LBBB resolved the day after TAVR in 35 patients (66%). In patients with new\u2010onset LBBB postvalve deployment and no infrahisian conduction delay intraprocedurally, the His\u2010ventricular interval did not prolong in any patient to &gt;55\u2009milliseconds the following day. Overall, 4 patients (7.5%) with new\u2010onset LBBB after TAVR were found to have persistent infrahisian conduction delay 24\u2009hours after TAVR. During 30\u2010day follow\u2010up, 1 patient (1.1%) with new LBBB and a normal His\u2010ventricular interval after TAVR developed new high\u2010grade atrioventricular block.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with new\u2010onset LBBB postvalve deployment, infrahisian conduction delay can safely be excluded intraprocedurally, suggesting that early intracardiac intraprocedural conduction studies may be of value in these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026239","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T12:08:47Z","timestamp":1658750927000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Value of Periprocedural Electrophysiology Testing During Transcatheter Aortic Valve Replacement for Risk Stratification of\u00a0Patients With New\u2010Onset Left Bundle\u2010Branch Block"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0557","authenticated-orcid":false,"given":"Patrick","family":"Badertscher","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-021X","authenticated-orcid":false,"given":"Sven","family":"Knecht","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9541","authenticated-orcid":false,"given":"Florian","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Auberson","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Salis","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-5491","authenticated-orcid":false,"given":"Raban V.","family":"Jeger","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Fahrni","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schaer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-6731","authenticated-orcid":false,"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-7050","authenticated-orcid":false,"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-3711","authenticated-orcid":false,"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel, University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24915"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02211.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-1-201301010-00007"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.035"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.033"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.014"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.050"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014446"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.023"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.03.009"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.961649"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-016-0218-2"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.02.015"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.03.024"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315967"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.068"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028352"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.01.215"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:26:02Z","timestamp":1715603162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":22,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,8,2]]}},"alternative-id":["10.1161\/JAHA.122.026239"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026239","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"2022-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026239"}}