{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:04:08Z","timestamp":1762254248273,"version":"3.41.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">To evaluate the prognostic value of plasma YKL\u201040 (human cartilage glycoprotein\u201039) for acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We measured plasma YKL\u201040 levels in 3377 participants from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). Study outcome data on death, major disability (modified Rankin Scale score \u22653), and vascular diseases were collected at 3\u2009months after stroke onset. The primary outcome was defined as a combination of death and major disability. During the 3\u2010month follow\u2010up, 828 participants (24.5%) experienced major disability or died. After multivariate adjustment, the highest YKL\u201040 quartile was associated with an increased risk of the primary outcome (odds ratio, 1.426 [95% CI, 1.105\u20131.839];\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.01) compared with the lowest quartile. Each SD increase in log\u2010transformed YKL\u201040 level was associated with a 15.5% (95% CI, 5.6\u201326.3%) increased risk of the primary outcome. The multivariable\u2010adjusted spline regression models showed a linear dose\u2013response relationship between YKL\u201040 and clinical outcomes. Adding YKL\u201040 to a model containing conventional risk factors significantly improved the reclassification power for the primary outcome (net reclassification improvement: 15.61%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; integrated discrimination index: 0.37%,\n              <jats:italic>P<\/jats:italic>\n              =0.004) and marginally significantly improved the discriminatory power for the primary outcome (area under the receiver operating characteristic curve improved by 0.003,\n              <jats:italic>P<\/jats:italic>\n              =0.099).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A higher YKL\u201040 level in the acute phase of ischemic stroke was associated with an increased risk of mortality and major disability at 3\u2009months after stroke, indicating that YKL\u201040 may play an important role as a prognostic marker of ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01840072.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026263","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:44:00Z","timestamp":1663148640000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Plasma Human Cartilage Glycoprotein\u201039 Is Associated With the Prognosis of Acute Ischemic Stroke"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-1622","authenticated-orcid":false,"given":"Tian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2314-6814","authenticated-orcid":false,"given":"Chongke","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-0014","authenticated-orcid":false,"given":"Zhengbao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-4852","authenticated-orcid":false,"given":"Xiaowei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University Suzhou 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