{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:06:49Z","timestamp":1791371209691,"version":"4.3.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,10,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The usefulness of preprocedural nutritional status to stratify prognosis after transcatheter aortic valve implantation has been evaluated; however, the studies conducted so far have been relatively small and\/or focused on a single nutritional index. This study sought to assess the prevalence and prognostic impact of malnutrition in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We applied the Controlling Nutritional Status score, Geriatric Nutritional Risk Index, and Prognostic Nutritional Index to 1040 consecutive older Japanese patients at high surgical risk who underwent transcatheter aortic valve implantation. According to the Controlling Nutritional Status score, Geriatric Nutritional Risk Index, and Prognostic Nutritional Index, 16.6%, 60.5%, and 13.8% patients had moderate or severe malnutrition, respectively; 89.3% were at least mildly malnourished by at least 1 score. Worse nutritional status was associated with older age, lower body mass index, higher degree of frailty, worse symptoms and renal function, atrial fibrillation, and anemia. During a median follow\u2010up of 986\u2009days (interquartile range, 556\u20131402\u2009days), 273 (26.3%) patients died. Compared with normal nutrition, malnutrition was associated with an increased risk for all\u2010cause death (adjusted hazard ratio for moderate and severe malnutrition, respectively: 2.19 (95% CI, 1.45\u20133.31;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and 6.13 (95% CI, 2.75\u201313.70;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for the Controlling Nutritional Status score, 2.02 (95% CI, 1.36\u20133.02;\n              <jats:italic>P<\/jats:italic>\n              =0.001) and 3.24 (95% CI, 1.86\u20135.65;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for the Geriatric Nutritional Risk Index, and 1.60 (95% CI, 1.06\u20132.39;\n              <jats:italic>P<\/jats:italic>\n              =0.024) and 2.32 (95% CI, 1.50\u20133.60;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) for the Prognostic Nutritional Index).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Malnutrition is common in patients undergoing transcatheter aortic valve implantation and is associated with increased mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026294","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T09:35:33Z","timestamp":1664444133000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and Prognostic Significance of Malnutrition in Older Japanese Adults at High Surgical Risk Undergoing Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-5525","authenticated-orcid":false,"given":"Kenichi","family":"Ishizu","sequence":"first","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu 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