{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:03Z","timestamp":1787018103852,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,12,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">ATP\u2010sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following prolonged global ischemia, making it an ideal candidate for use during cardiac surgery. We hypothesized that diazoxide would reduce myocardial stunning after regional ischemia with subsequent prolonged global ischemia, similar to the clinical situation of myocardial ischemia at the time of revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Swine underwent left anterior descending occlusion (30\u2009minutes), followed by 120\u2009minutes global ischemia protected with hyperkalemic cardioplegia\u00b1diazoxide (N=6 each), every 20\u2009minutes cardioplegia, then 60\u2009minutes reperfusion. Cardiac output, time to wean from cardiopulmonary bypass, left ventricular (LV) function, caspase\u20103, and infarct size were compared. Six animals in the diazoxide group separated from bypass by 30\u2009minutes, whereas only 4 animals in the cardioplegia group separated. Diazoxide was associated with shorter but not significant time to wean from bypass (17.5 versus 27.0\u2009minutes;\n                      <jats:italic>P<\/jats:italic>\n                      =0.13), higher, but not significant, cardiac output during reperfusion (2.9 versus 1.5\u2009L\/min at 30\u2009minutes;\n                      <jats:italic>P<\/jats:italic>\n                      =0.05), and significantly higher left ventricular ejection fraction at 30\u2009minutes (42.5 versus 15.8%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Linear mixed regression modeling demonstrated greater left ventricular developed pressure (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and maximum change in ventricular pressure during isovolumetric contraction (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) in the diazoxide group at 30\u2009minutes of reperfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Diazoxide reduces myocardial stunning and facilitates separation from cardiopulmonary bypass in a model that mimics the clinical setting of ongoing myocardial ischemia before revascularization. Diazoxide has the potential to reduce myocardial stunning in the clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.026304","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T06:09:56Z","timestamp":1669702196000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["ATP\u2014Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model"],"prefix":"10.1161","volume":"11","author":[{"given":"Ana K.","family":"Velez","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery Johns Hopkins University School of Medicine Baltimore 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