{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:51:14Z","timestamp":1792479074858,"version":"4.5.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Fine particulate (fine particles with aerodynamic diameters \u22642.5\u2009\u03bcm [PM\n              <jats:sub>2.5<\/jats:sub>\n              ]) exposure has been associated with a risk of cardiac arrhythmias in adults. However, the association between PM\n              <jats:sub>2.5<\/jats:sub>\n              exposure and cardiac arrhythmias in adolescents remains unclear.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              To investigate the association and time course between PM\n              <jats:sub>2.5<\/jats:sub>\n              exposure with cardiac arrhythmias in adolescents, we analyzed the data collected from 322 adolescents who participated in the PSCC (Penn State Child Cohort) follow\u2010up examination. We obtained individual\u2010level 24\u2010hour PM\n              <jats:sub>2.5<\/jats:sub>\n              concentrations with a nephelometer. Concurrent with the PM\n              <jats:sub>2.5<\/jats:sub>\n              measure, we obtained 24\u2010hour ECG data using a Holter monitor, from which cardiac arrhythmias, including premature atrial contractions and premature ventricular contractions (PVCs), were identified. PM\n              <jats:sub>2.5<\/jats:sub>\n              concentration and numbers of premature atrial contractions\/PVCs were summarized into 30\u2010minute\u2010based segments. Polynomial distributed lag models within a framework of a negative binomial model were used to assess the effect of PM\n              <jats:sub>2.5<\/jats:sub>\n              concentration on numbers of premature atrial contractions and PVCs. PM\n              <jats:sub>2.5<\/jats:sub>\n              exposure was associated with an acute increase in number of PVCs. Specifically, a 10\u2009\u03bcg\/m\n              <jats:sup>3<\/jats:sup>\n              increase in PM\n              <jats:sub>2.5<\/jats:sub>\n              concentration was associated with a 2% (95% CI, 0.4%\u20133.3%) increase in PVC counts 0.5 to 1.0, 1.0 to 1.5, and 1.5 to 2.0\u2009hours after the exposure. Cumulatively, a 10\u2009\u03bcg\/m\n              <jats:sup>3<\/jats:sup>\n              increment in PM\n              <jats:sub>2.5<\/jats:sub>\n              was associated with a 5% (95% CI, 1%\u201310%) increase in PVC counts within 2\u2009hours after exposure. PM\n              <jats:sub>2.5<\/jats:sub>\n              concentration was not associated with premature atrial contraction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              PM\n              <jats:sub>2.5<\/jats:sub>\n              exposure was associated with an acute increased number of ventricular arrhythmias in a population\u2010based sample of adolescents. The time course of the effect of PM\n              <jats:sub>2.5<\/jats:sub>\n              on ventricular arrhythmia is within 2\u2009hours after exposure.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026370","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:42:48Z","timestamp":1663148568000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Acute Impact of Fine Particulate Air Pollution on Cardiac Arrhythmias in a Population\u2010Based Sample of Adolescents: The Penn State Child Cohort"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-9999","authenticated-orcid":false,"given":"Fan","family":"He","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff D.","family":"Yanosky","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-6161","authenticated-orcid":false,"given":"Julio","family":"Fernandez\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon M.","family":"Chinchilli","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Al\u2010Shaar","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros N.","family":"Vgontzas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward O.","family":"Bixler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health, Sleep Research and Treatment Center Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanping","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304521"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2016:11:2"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.08.026"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020254"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510687"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.017228"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0221-2"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302549"},{"key":"e_1_3_1_10_2","first-page":"1717","article-title":"Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis","volume":"38","author":"Lazzerini PE","year":"2017","unstructured":"Lazzerini PE, Capecchi PL, Laghi\u2010Pasini F. 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