{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:08:55Z","timestamp":1793653735594,"version":"4.5.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Whether pulmonary hemodynamic parameters and functional capacity are associated with quality of life in patients with chronic thromboembolic pulmonary hypertension remains unknown. This study aimed to evaluate disease\u2010specific quality of life using the emPHasis\u201010 questionnaire and assess its determinants in patients with chronic thromboembolic pulmonary hypertension with normalized pulmonary hemodynamics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This cross\u2010sectional study included 187 health status assessments of 143 patients with chronic thromboembolic pulmonary hypertension (median age, 68 [58\u201375] years; men\/women, 51\/136; use of home oxygen therapy, 51 patients [27%]) after balloon pulmonary angioplasty with normalized mean pulmonary artery pressure &lt;25\u2009mm\u2009Hg at rest. Right heart catheterization was performed, followed by assessment of 6\u2010minute walk distance and the emPHasis\u201010 questionnaire. The median pulmonary artery pressure and pulmonary vascular resistance were 18 (15\u201321) mm\u2009Hg and 2.2 (1.7\u20132.9) wood units, respectively. The median emPHasis\u201010 score was 14 (8\u201324), whereas the median 6\u2010minute walk distance was 447 (385\u2013517)\u00a0m. Univariate linear regression analysis showed that the emPHasis\u201010 score was associated with 6\u2010minute walk distance (\u03b2=\u22120.476 [95% CI \u22120.604, \u22120.348],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and home oxygen therapy (\u03b2=0.214 [95% CI, 0.072, 0.356],\n              <jats:italic>P<\/jats:italic>\n              =0.003) but not with hemodynamic parameters. Multiple regression analysis revealed that a higher emPHasis\u201010 score was associated with lower 6\u2010minute walk distance (\u03b2=\u22120.475 [95% CI, \u22120.631 to \u22120.319],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Health\u2010related quality of life was associated with exercise capacity and the use of home oxygen therapy, but not with hemodynamic parameters, in patients with chronic thromboembolic pulmonary hypertension and normalized hemodynamics after balloon pulmonary angioplasty. Improvements in exercise capacity may lead to further improvements in quality of life.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026400","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T09:20:46Z","timestamp":1662196846000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["EmPHasis\u201010 Health\u2010Related Quality of Life and Exercise Capacity in Chronic Thromboembolic Pulmonary Hypertension After Balloon Angioplasty"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-5036","authenticated-orcid":false,"given":"Hayato","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-7639","authenticated-orcid":false,"given":"Ayumi","family":"Goda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-8110","authenticated-orcid":false,"given":"Kaori","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Inami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4437-8019","authenticated-orcid":false,"given":"Yuichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension Center International University of Health and Welfare Mita Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-4563","authenticated-orcid":false,"given":"Kyoko","family":"Soejima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-1966","authenticated-orcid":false,"given":"Toru","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyorin University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-92"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.04.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0063-2015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01626-2015"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094587"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0011-3840(00)80005-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024201"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01982-2019"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001602"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.01.237"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01919-2018"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.542"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127113"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-20-0014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.12.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.03.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00124-2020"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318819161"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9472-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1712-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0538"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2020.02.015"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0483-x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00414-2020"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00109-2020"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052899"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv337"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618397"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.026"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041603"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309230"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-206865"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000263"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-9"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:58:26Z","timestamp":1715605106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":36,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,9,6]]}},"alternative-id":["10.1161\/JAHA.122.026400"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026400","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026400"}}