{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:57:10Z","timestamp":1792515430879,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Rheumatic immune mediated inflammatory diseases (IMIDs) are associated with high risk of acute coronary syndrome. The long\u2010term prognosis of acute coronary syndrome in patients with rheumatic IMIDs is not well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We identified Medicare beneficiaries admitted with a primary diagnosis of myocardial infarction (MI) from 2014 to 2019. Outcomes of patients with MI and concomitant rheumatic IMIDs including systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, dermatomyositis, or psoriasis were compared with propensity matched control patients without rheumatic IMIDs. One\u2010to\u2010three propensity\u2010score matching was done for exact age, sex, race, ST\u2010segment\u2013elevation MI, and non\u2013ST\u2010segment\u2013elevation MI variables and greedy approach on other comorbidities. The study primary outcome was all\u2010cause mortality. The study cohort included 1\u2009654\u2009862 patients with 3.6% prevalence of rheumatic IMIDs, the most common of which was rheumatoid arthritis, followed by systemic lupus erythematosus. Patients with rheumatic IMIDs were younger, more likely to be women, and more likely to present with non\u2013ST\u2010segment\u2013elevation MI. Patients with rheumatic IMIDs were less likely to undergo coronary angiography, percutaneous coronary intervention or coronary artery bypass grafting. After propensity\u2010score matching, at median follow up of 24 months (interquartile range 9\u201345), the risk of mortality (adjusted hazard ratio [HR], 1.15 [95% CI, 1.14\u20131.17]), heart failure (HR, 1.12 [95% CI 1.09\u20131.14]), recurrent MI (HR, 1.08 [95% CI 1.06\u20131.11]), and coronary reintervention (HR, 1.06 [95% CI, 1.01\u20131.13]) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05 for all) was higher in patients with versus without rheumatic IMIDs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with MI and rheumatic IMIDs have higher risk of mortality, heart failure, recurrent MI, and need for coronary reintervention during follow\u2010up compared with patients without rheumatic IMIDs.<\/jats:p>\n                  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