{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:11:51Z","timestamp":1777403511420,"version":"3.51.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Microparticles and endothelial microparticles (EMPs) are implicated in accelerating cardiovascular disease (CVD); however, data in pediatrics are limited. We examined the relationship of microparticles and EMPs with adiposity and subclinical CVD risk measures in a pediatric population to determine their potential as biomarkers of CVD risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A cross\u2010sectional study of youth (n=280; ages 8\u201320\u2009years) with a range of body mass index categories was used. Microparticles, EMPs, and activated EMPs were measured by flow cytometry. %Body fat and %visceral adipose tissue were measured by dual X\u2010ray absorptiometry. Measures of arterial stiffness and vascular wall structure were obtained. Linear regression (with log\u2010transformed outcomes) and logistic regression were used to evaluate associations and all results were exponentiated. Youth with overweight\/obesity and severe obesity had 2.50 (95% CI, 1.56\u20134.01) and 3.42 (95% CI, 2.15\u20135.43) times the geometric means of the total number of microparticles, respectively, compared with those with normal weight. Youth with overweight\/obesity and severe obesity had 1.97 (95% CI, 1.09\u20133.55) and 2.34 (95% CI, 1.31\u20134.19) times the geometric means of the total number of EMPs, respectively, compared with those with normal weight. There were positive associations between the levels of both microparticles and EMPs with higher adiposity measures and poor CVD risk measures. Youth with higher adiposity showed 1.84 times the odds of having high levels of activated EMPs (%) (odds ratio, 1.84; 95% CI, 1.08\u20133.14) compared with those with normal weight.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Levels of microparticles, EMPs, and activated EMPs were positively associated with adiposity and poor subclinical CVD risk in a pediatric population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026430","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T10:30:08Z","timestamp":1667471408000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship of Endothelial Microparticles to Obesity and Cardiovascular Disease Risk in Children and Adolescents"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-8487","authenticated-orcid":false,"given":"Subin","family":"Jang","sequence":"first","affiliation":[{"name":"Division of Epidemiology, School of Public Health University of Minnesota Minneapolis MN"},{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise F.","family":"Palzer","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle D.","family":"Rudser","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health University of Minnesota Minneapolis MN"},{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia K.","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-7933","authenticated-orcid":false,"given":"Robert P.","family":"Hebbel","sequence":"additional","affiliation":[{"name":"Vascular Biology Center, Division of Hematology, Oncology &amp; Transplantation University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Medicine University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Dengel","sequence":"additional","affiliation":[{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis MN"},{"name":"School of Kinesiology University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-699X","authenticated-orcid":false,"given":"Liming","family":"Milbauer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-9497","authenticated-orcid":false,"given":"Justin R.","family":"Ryder","sequence":"additional","affiliation":[{"name":"Center for Pediatric Obesity Medicine University of Minnesota Medical School Minneapolis MN"},{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.652859"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801387-8.00015-6"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i11.1135"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/734509"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2741\/1270"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082212"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096024"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.8.841"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu153"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0851"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21681"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080228"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2019-0229"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.018092"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.007467"},{"key":"e_1_3_1_17_2","unstructured":"Kuczmarski RJ Ogden CL Guo SS Grummer\u2010Strawn LM Flegal KM Mei Z Wei R Curtin LR Roche AF Johnson CL. 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