{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:18:06Z","timestamp":1785014286565,"version":"3.55.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,10,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We describe sex\u2010differential disease patterns and outcomes of &gt;20.6\u00a0million cardiovascular emergency department encounters in the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed primary cardiovascular encounters from the Nationwide Emergency Department Sample between 2016 and 2018. We grouped cardiovascular diagnoses into 15 disease categories. The sample included 48.7% women; median age was 67 (interquartile range, 54\u201378) years. Men had greater overall baseline comorbidity burden; however, women had higher rates of obesity, hypertension, and cerebrovascular disease. For women, the most common emergency department encounters were essential hypertension (16.0%), hypertensive heart or kidney disease (14.1%), and atrial fibrillation\/flutter (10.2%). For men, the most common encounters were hypertensive heart or kidney disease (14.7%), essential hypertension (10.8%), and acute myocardial infarction (10.7%). Women were more likely to present with essential hypertension, hypertensive crisis, atrial fibrillation\/flutter, supraventricular tachycardia, pulmonary embolism, or ischemic stroke. Men were more likely to present with acute myocardial infarction or cardiac arrest. In logistic regression models adjusted for baseline covariates, compared with men, women with intracranial hemorrhage had higher risk of hospitalization and death. Women presenting with pulmonary embolism or deep vein thrombosis were less likely to be hospitalized. Women with aortic aneurysm\/dissection had higher odds of hospitalization and death. Men were more likely to die following presentations with hypertensive heart or kidney disease, atrial fibrillation\/flutter, acute myocardial infarction, or cardiac arrest.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this large nationally representative sample of cardiovascular emergency department presentations, we demonstrate significant sex differences in disease distribution, hospitalization, and death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026432","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T10:37:45Z","timestamp":1662633465000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Differential Patterns and Outcomes of 20.6\u00a0Million Cardiovascular Emergency Department Encounters for Men and Women in the United States"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-5465","authenticated-orcid":false,"given":"Zahra","family":"Raisi\u2010Estabragh","sequence":"first","affiliation":[{"name":"National Institute for Heart Research Barts Biomedical Research Centre, Centre for Advanced Cardiovascular Imaging William Harvey Research Institute, Queen Mary University London London United Kingdom"},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health National Health Service Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Kobo","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Keele University Keele United Kingdom"},{"name":"Department of Cardiology Hillel Yaffe Medical Center Hadera Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-781X","authenticated-orcid":false,"given":"Ayman","family":"Elbadawi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Division of Cardiology, Baylor College of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Velagapudi","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-2077","authenticated-orcid":false,"given":"Garima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease Johns Hopkins University School of Medicine and Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee P.","family":"Bullock\u2010Palmer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Deborah Heart and Lung Center Brown Mills NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-5160","authenticated-orcid":false,"given":"Steffen E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"National Institute for Heart Research Barts Biomedical Research Centre, Centre for Advanced Cardiovascular Imaging William Harvey Research Institute, Queen Mary University London London United Kingdom"},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health National Health Service Trust London United Kingdom"},{"name":"Health Data Research UK London United Kingdom"},{"name":"Alan Turing Institute London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-1930","authenticated-orcid":false,"given":"Laxmi S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0309","authenticated-orcid":false,"given":"Waqas","family":"Ullah","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Hospitals Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hillel Yaffe Medical Center Hadera Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-3115","authenticated-orcid":false,"given":"Louise Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Cardiac Anesthesiology University of Ottawa Heart Institute Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group Keele University Keele United Kingdom"},{"name":"Institute of Population Health University of Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab892"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968792"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz898"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0643-8"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494815618843"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02290.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-6-155"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0580-0"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215649"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664979"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037655"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.09.001"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1300\/J013v17n02_05"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06862-x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2017.01.003"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.10.022"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1481803500012550"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014733"},{"key":"e_1_3_1_20_2","unstructured":"Overview of the Nationwide Emergency Department Sample (NEDS) . Available at: https:\/\/www.hcup\u2010us.ahrq.gov\/nedsoverview.jsp. Accessed January 2 2022."},{"key":"e_1_3_1_21_2","unstructured":"Checklist for Working with the NEDS . Available at: https:\/\/www.hcup\u2010us.ahrq.gov\/db\/nation\/neds\/nedschecklist.jsp. Accessed June 26 2022."},{"key":"e_1_3_1_22_2","unstructured":"HCUP Methods Series Hierarchical Modeling using HCUP Data Report# 2007\u201001. Available at: http:\/\/www.hcup\u2010us.ahrq.gov\/reports\/methods.jsp. Accessed June 26 2022."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000500205"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.002"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028981"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.05.042"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1995.tb03172.x"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060711"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014742"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2468"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307547"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2017-000298"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.5306"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000912"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4247"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029652"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.4.356"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:24:43Z","timestamp":1715603083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2022,10,4]]}},"alternative-id":["10.1161\/JAHA.122.026432"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026432","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"2022-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026432"}}