{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:05Z","timestamp":1787018105307,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real\u2010time magnetic resonance imaging, beat\u2010to\u2010beat physiological monitoring, and orthostatic stress testing through lower\u2010body negative pressure (LBNP). We conducted a proof\u2010of\u2010concept study in a patient with severe orthostatic hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included a 46\u2010year\u2010old man with pure autonomic failure. Without and during \u221230\u00a0\n                      <jats:styled-content style=\"fixed-case\">mmHg LBNP<\/jats:styled-content>\n                      , we obtained\n                      <jats:styled-content style=\"fixed-case\">3T<\/jats:styled-content>\n                      real\u2010time magnetic resonance imaging of the cardiac short axis and quantitative flow measurements in the pulmonary trunk and middle cerebral artery. Blood pressure was 118\/74\u00a0\n                      <jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>\n                      during supine rest and 58\/35\u00a0\n                      <jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>\n                      with\n                      <jats:styled-content style=\"fixed-case\">LBNP<\/jats:styled-content>\n                      . With\n                      <jats:styled-content style=\"fixed-case\">LBNP<\/jats:styled-content>\n                      , left ventricular stroke volume decreased by 44.6%, absolute middle cerebral artery flow by 37.6%, and pulmonary trunk flow by 40%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Combination of real\u2010time magnetic resonance imaging,\n                      <jats:styled-content style=\"fixed-case\">LBNP<\/jats:styled-content>\n                      , and continuous blood pressure monitoring provides a promising new approach to study orthostatic intolerance mechanisms in human beings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.026437","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T06:57:57Z","timestamp":1666853877000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-6065","authenticated-orcid":false,"given":"Darius A.","family":"Gerlach","sequence":"first","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-4806","authenticated-orcid":false,"given":"Andrea","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-1448","authenticated-orcid":false,"given":"Jorge","family":"Manuel","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"},{"name":"Institute for Neuroradiology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Bach","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-6649","authenticated-orcid":false,"given":"Alex","family":"Hoff","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-1446","authenticated-orcid":false,"given":"Jan\u2010Niklas","family":"H\u00f6nemann","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"},{"name":"Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-5585","authenticated-orcid":false,"given":"Karsten","family":"Heusser","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Voit","sequence":"additional","affiliation":[{"name":"Biomedical NMR Max Planck Institute for Multidisciplinary Sciences G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-884X","authenticated-orcid":false,"given":"Jens","family":"Frahm","sequence":"additional","affiliation":[{"name":"Biomedical NMR Max Planck Institute for Multidisciplinary Sciences G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-0706","authenticated-orcid":false,"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"},{"name":"Medical Faculty University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5672-1187","authenticated-orcid":false,"given":"Jens","family":"Tank","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center (DLR) Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(98)00364-7"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1585"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25696"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00193"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(94)00135-7"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199105000-00002"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200062"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80023-3"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.7.1672"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3301.094908"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:37:22Z","timestamp":1715589442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":12,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1161\/JAHA.122.026437"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026437","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026437"}}