{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:48:29Z","timestamp":1767862109073,"version":"3.49.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,3,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Diabetes and hypertension have been associated with adverse left ventricular (LV) remodeling. While they often occur concurrently, their individual effects are understudied. We aimed to assess the independent effects of diabetes and hypertension on LV remodeling in Black adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The\u00a0JHS (Jackson Heart Study) participants (n=4143 Black adults) with echocardiographic measures from baseline exam were stratified into 4 groups: neither diabetes nor hypertension (n=1643), only diabetes (n=152), only hypertension (n=1669), or both diabetes and hypertension (n=679). Echocardiographic measures of LV structure and function among these groups were evaluated by multivariable regression adjusting for covariates. Mean age of the participants was 52\u00b11\u2009years, and 63.7% were women. LV mass index was not different in participants with only diabetes compared with participants with neither diabetes nor hypertension (\n              <jats:italic>P<\/jats:italic>\n              =0.8). LV mass index was 7.9% (6.0\u2009g\/m\n              <jats:sup>2<\/jats:sup>\n              ) higher in participants with only hypertension and 10.8% (8.1\u2009g\/m\n              <jats:sup>2<\/jats:sup>\n              ) higher in participants with both diabetes and hypertension compared with those with neither (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). LV wall thickness (relative, posterior, and septal) and brain natriuretic peptide levels in participants with only diabetes were not significantly higher than participants with neither (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). However, participants with both diabetes and hypertension demonstrated higher LV wall thickness and brain natriuretic peptide levels than participants with neither (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this cross\u2010sectional analysis, diabetes was not associated with altered LV structure or function in Black adults unless participants also had hypertension. Our findings suggest hypertension is the main contributor to cardiac structural and functional changes in Black adults with diabetes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026463","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T18:21:24Z","timestamp":1682619684000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Diabetes and Hypertension on Left Ventricular Structure and Function: The Jackson Heart Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-2567","authenticated-orcid":false,"given":"Arsalan","family":"Hamid","sequence":"first","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wondwosen K.","family":"Yimer","sequence":"additional","affiliation":[{"name":"Department of Data Science University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-8184","authenticated-orcid":false,"given":"Adebamike A.","family":"Oshunbade","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-2160","authenticated-orcid":false,"suffix":"III","given":"Donald","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"},{"name":"Division of Cardiology, Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin R.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"},{"name":"Division of Cardiology, Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-0004","authenticated-orcid":false,"given":"Yuan\u2010I","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5492","authenticated-orcid":false,"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8834","authenticated-orcid":false,"given":"Daichi","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University Medical Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3836","authenticated-orcid":false,"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-4451","authenticated-orcid":false,"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Harvard University Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-1719","authenticated-orcid":false,"given":"Robert J.","family":"Mentz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University Durham NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-729X","authenticated-orcid":false,"given":"Daniel W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain G.","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Wake Forest University Winston\u2010Salem NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-5855","authenticated-orcid":false,"given":"John E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-600X","authenticated-orcid":false,"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-4720","authenticated-orcid":false,"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"},{"name":"Baylor Scott and White Research Institute Dallas TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-1025","authenticated-orcid":false,"given":"Michael E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center Jackson MS"},{"name":"Division of Cardiology, Department of Medicine University of Mississippi Medical Center Jackson MS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00582-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.03.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2583"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.19.2271"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.102"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001990"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.02.033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01516-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2008.133892"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.061"},{"key":"e_1_3_2_13_2","first-page":"175","article-title":"Racial and ethnic differences in hypertension risk: new diagnoses after age 50","volume":"22","author":"Quinones AR","year":"2012","unstructured":"Quinones AR, Liang J, Ye W. Racial and ethnic differences in hypertension risk: new diagnoses after age 50. Ethn Dis. 2012;22:175\u2013180.","journal-title":"Ethn Dis"},{"key":"e_1_3_2_14_2","unstructured":"Jackson Heart Study\n. Data and Materials distribution agreement 2018. Accessed July 5th 2021. https:\/\/www.jacksonheartstudy.org\/Portals\/0\/pdf\/DataMaterialsDistributionAgreementDMDA.pdf"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031912"},{"key":"e_1_3_2_16_2","first-page":"S6\u20104","article-title":"Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study","volume":"15","author":"Taylor HA","year":"2005","unstructured":"Taylor HA Jr, Wilson JG, Jones DW, Sarpong DF, Srinivasan A, Garrison RJ, Nelson C, Wyatt SB. Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study. Ethn Dis. 2005;15:S6\u20104\u2013S6\u201017.","journal-title":"Ethn Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200409000-00001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000900"},{"key":"e_1_3_2_20_2","first-page":"S6\u201018","article-title":"Recruiting African\u2010American research participation in the Jackson Heart Study: methods, response rates, and sample description","volume":"15","author":"Fuqua SR","year":"2005","unstructured":"Fuqua SR, Wyatt SB, Andrew ME, Sarpong DF, Henderson FR, Cunningham MF, Taylor HA Jr. Recruiting African\u2010American research participation in the Jackson Heart Study: methods, response rates, and sample description. Ethn Dis. 2005;15:S6\u201018\u2013S6\u201029.","journal-title":"Ethn Dis."},{"key":"e_1_3_2_21_2","first-page":"S6\u201056","article-title":"Physical activity assessment methods in the Jackson Heart Study","volume":"15","author":"Dubbert PM","year":"2005","unstructured":"Dubbert PM, Carithers T, Ainsworth BE, Taylor HA Jr, Wilson G, Wyatt SB. Physical activity assessment methods in the Jackson Heart Study. Ethn Dis. 2005;15:S6\u201056\u2013S6\u201061.","journal-title":"Ethn Dis."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000379"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm605"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000509"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2013.0109"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T04:40:17Z","timestamp":1719031217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3,21]]}},"alternative-id":["10.1161\/JAHA.122.026463"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026463","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,21]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026463"}}