{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:30:30Z","timestamp":1776501030978,"version":"3.51.2"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Atherosclerosis vulnerability regression has been evidenced mostly in randomized clinical trials with intensive lipid\u2010lowering therapy. We aimed to demonstrate vulnerability regression in real life, with a comprehensive quantitative method, in patients with asymptomatic mild to moderate carotid atherosclerosis on a secondary prevention program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a single\u2010center prospective observational study (MAGNETIC [Magnetic Resonance Imaging as a Gold Standard for Noninvasive Evaluation of Atherosclerotic Involvement of Carotid Arteries]): 260 patients enrolled at a cardiac rehabilitation center were followed for 3\u2009years with serial magnetic resonance imaging. Per section cutoffs (95th\/5th percentiles) were derived from a sample of 20 consecutive magnetic resonance imaging scans: (1) lipid\u2010rich necrotic core: 26% of vessel wall area; (2) intraplaque hemorrhage: 12% of vessel wall area; and (3) fibrous cap: (a) minimum thickness: 0.06\u2009mm, (b) mean thickness: 0.4\u2009mm, (c) projection length: 11\u2009mm. Patients with baseline magnetic resonance imaging of adequate quality (n=247) were classified as high (n=63, 26%), intermediate (n=65, 26%), or low risk (n=119, 48%), if vulnerability criteria were fulfilled in \u22652 contiguous sections, in 1 or multiple noncontiguous sections, or in any section, respectively. Among high\u2010risk patients, a conversion to any lower\u2010risk status was found in 11 (17%;\n              <jats:italic>P<\/jats:italic>\n              =0.614) at 6\u2009months, in 16 (25%;\n              <jats:italic>P<\/jats:italic>\n              =0.197) at 1 year, and in 19 (30%;\n              <jats:italic>P<\/jats:italic>\n              =0.009) at 3\u2009years. Among patients showing any degree of carotid plaque vulnerability, 21 (16%;\n              <jats:italic>P<\/jats:italic>\n              =0.014) were diagnosed at low risk at 3\u2009years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study demonstrates with a quantitative approach that vulnerability regression is common in real life. A secondary prevention program can promote vulnerability regression in asymptomatic patients in the mid to long term.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026469","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T10:06:50Z","timestamp":1673431610000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Evidence of Carotid Atherosclerosis Vulnerability Regression in Real Life From Magnetic Resonance Imaging: Results of the MAGNETIC Prospective Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-6113","authenticated-orcid":false,"given":"Oronzo","family":"Catalano","sequence":"first","affiliation":[{"name":"Division of Cardiology Istituti Clinici Scientifici Maugeri IRCCS Pavia 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