{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:11:54Z","timestamp":1785017514494,"version":"3.55.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,10,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to determine the associations of childhood maltreatment with incident heart failure in later life and explore the potentially modifying effects of genetic risk for heart failure on the associations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This cohort study included adults free of heart failure at baseline enrolled between 2006 and 2010 in the UK Biobank. Childhood maltreatment was retrospectively assessed with the online Childhood Trauma Screener in 2016. Five types of childhood maltreatment (range, 0\u20135), including physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse, were combined into a total score. A weighted polygenic risk score for heart failure was constructed. Incident all\u2010cause heart failure was prospectively ascertained via hospital inpatient and death records, followed up to May 31, 2021. A total of 153\u2009287 adults (mean [SD] age, 55.9 [7.7] years; 43.6% male) were included. Over a median of 12.2\u2009years (interquartile range, 11.5\u201312.9\u2009years) of follow\u2010up, 2352\u00a0participants had incident heart failure. Childhood maltreatment was associated with a greater risk of incident heart failure in a dose\u2010response manner. One additional type of childhood maltreatment was associated with a 15% increase in the risk of developing heart failure (hazard ratio [HR], 1.15 [95% CI, 1.07\u20131.23]). There was no statistically significant interaction between genetic risk and childhood maltreatment (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.218). Among participants with high genetic risk, those with 3 to 5 types of childhood maltreatment had a double hazard (HR, 2.00 [95% CI, 1.43\u20132.80]) of developing heart failure when taking those without any childhood maltreatment as the reference.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Irrespective of genetic risk for heart failure, childhood maltreatment was associated with an increased risk of incident heart failure in a dose\u2010dependent manner.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026536","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T11:08:57Z","timestamp":1664968137000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Associations of Childhood Maltreatment and Genetic Risks With Incident Heart Failure in Later 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Xinxiang Medical University Weihui Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foqian","family":"Weng","sequence":"additional","affiliation":[{"name":"School of Medicine Jinan University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-7780","authenticated-orcid":false,"given":"Hongliang","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-2522","authenticated-orcid":false,"given":"Lulu","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong 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