{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:42:09Z","timestamp":1793191329883,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p xml:lang=\"en\">More than half of major adverse cardiovascular events (MACE) occur in the absence of obstructive coronary artery disease and are often attributed to the rupture of high\u2010risk coronary atherosclerotic plaque (HRP). Blood\u2010based biomarkers that associate with imaging\u2010defined HRP and predict MACE are lacking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>METHODS AND RESULTS<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Nuclear magnetic resonance\u2013based lipoprotein particle profiling was performed in the biomarker substudy of the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial (N=4019) in participants who had stable symptoms suspicious for coronary artery disease. Principal components analysis was used to reduce the number of correlated lipoproteins into uncorrelated lipoprotein factors. The association of lipoprotein factors and individual lipoproteins of significantly associated factors with core laboratory determined coronary computed tomographic angiography features of HRP was determined using logistic regression models. The association of HRP\u2010associated lipoproteins with MACE was assessed in the PROMISE trial and validated in an independent coronary angiography biorepository (CATHGEN [Catheterization Genetics]) using Cox proportional hazards models. Lipoprotein factors composed of high\u2010density lipoprotein (HDL) subclasses were associated with HRP. In these factors, large HDL (odds ratio [OR], 0.70 [95% CI, 0.56\u20130.85];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and medium HDL (OR, 0.84 [95% CI, 0.72\u20130.98];\n              <jats:italic>P<\/jats:italic>\n              =0.028) and HDL size (OR, 0.82 [95% CI, 0.69\u20130.96];\n              <jats:italic>P<\/jats:italic>\n              =0.018) were associated with HRP in multivariable models. Medium HDL was associated with MACE in PROMISE (hazard ratio [HR], 0.76 [95% CI, 0.63\u20130.92];\n              <jats:italic>P<\/jats:italic>\n              =0.004), which was validated in the CATHGEN biorepository (HR, 0.91 [95% CI, 0.88\u20130.94];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p xml:lang=\"en\">Large and medium HDL subclasses and HDL size inversely associate with HRP features, and medium HDL subclasses inversely associate with MACE in PROMISE trial participants. These findings may aid in the risk stratification of individuals with chest pain and provide insight into the pathobiology of HRP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>REGISTRATION<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01174550\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026662","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T10:36:48Z","timestamp":1671878208000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Lipoprotein Subclasses Associated With High\u2010Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-7152","authenticated-orcid":false,"given":"Robert W.","family":"McGarrah","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Duke Molecular Physiology Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-2223","authenticated-orcid":false,"given":"Maros","family":"Ferencik","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-5156","authenticated-orcid":false,"given":"Stephanie N.","family":"Giamberardino","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-769X","authenticated-orcid":false,"given":"Udo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center Harvard Medical School\u2013Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4827","authenticated-orcid":false,"given":"Borek","family":"Foldyna","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center Harvard Medical School\u2013Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-6260","authenticated-orcid":false,"given":"Julia","family":"Karady","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center Harvard Medical School\u2013Massachusetts General Hospital Boston MA"},{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-9808","authenticated-orcid":false,"given":"Geoffrey S.","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Duke Center for Applied Genomics &amp; Precision Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-9684","authenticated-orcid":false,"given":"William E.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Duke Molecular Physiology Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-4049","authenticated-orcid":false,"given":"Pamela S.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-2830","authenticated-orcid":false,"given":"Svati H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Duke Molecular Physiology Institute Duke University School of Medicine Durham NC"},{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005543"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.065"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005973"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001047"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht293"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024360"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.069"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.039"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000251503.35795.4f"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-7-200904070-00007"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.060"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.01.012"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.4973"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415516"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2016.10.002"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315701"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-015-9648-y"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.024"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000344"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.02.019"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P069039"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.017"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-9-118"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.11.015"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.04.004"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.538"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312645"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.122.026662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:59:50Z","timestamp":1715605190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.122.026662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,3]]}},"alternative-id":["10.1161\/JAHA.122.026662"],"URL":"https:\/\/doi.org\/10.1161\/jaha.122.026662","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"assertion":[{"value":"2022-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e026662"}}