{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:13:04Z","timestamp":1780528384694,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">For patients with atrial fibrillation seen in the emergency department (ED) following a transient ischemic attack (TIA) or minor stroke, the impact of initiating oral anticoagulation immediately rather than deferring the decision to outpatient follow\u2010up is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted a planned secondary data analysis of a prospective cohort of 11\u2009507 adults in 13 Canadian EDs between 2006 and 2018. Patients were eligible if they were aged 18\u2009years or older, with a final diagnosis of TIA or minor stroke with previously documented or newly diagnosed atrial fibrillation. The primary outcome was subsequent stroke, recurrent TIA, or all\u2010cause mortality within 90\u2009days of the index TIA diagnosis. Secondary outcomes included stroke, recurrent TIA, or death and rates of major bleeding. Of 11\u2009507 subjects with TIA\/minor stroke, atrial fibrillation was identified in 11.2% (1286, mean age, 77.3 [SD 11.1] years, 52.4% male). Over half (699; 54.4%) were already taking anticoagulation, 89 (6.9%) were newly prescribed anticoagulation in the ED. By 90\u2009days, 4.0% of the atrial fibrillation cohort had experienced a subsequent stroke, 6.5% subsequent TIA, and 2.6% died. Results of a multivariable logistic regression indicate no association between prescribed anticoagulation in the ED and these 90\u2010day outcomes (composite odds ratio, 1.37 [95% CI, 0.74\u20132.52]). Major bleeding was found in 5 patients, none of whom were in the ED\u2010initiated anticoagulation group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Initiating oral anticoagulation in the ED following new TIA was not associated with lower recurrence rates of neurovascular events or all\u2010cause mortality in patients with atrial fibrillation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026681","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:34:38Z","timestamp":1680863678000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Ninety\u2010Day Stroke or Transient Ischemic Attack Recurrence in Patients Prescribed Anticoagulation in the Emergency Department With Atrial Fibrillation and a New Transient Ischemic Attack or Minor Stroke"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-3655","authenticated-orcid":false,"given":"Graham","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-342X","authenticated-orcid":false,"given":"Mukul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Neurology McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-2721","authenticated-orcid":false,"given":"Debra","family":"Eagles","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Ottawa Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-1984","authenticated-orcid":false,"given":"Marie\u2010Joe","family":"Nemnom","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-1118","authenticated-orcid":false,"given":"Marco L. A.","family":"Sivilotti","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Queen\u2019s University Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-8110","authenticated-orcid":false,"given":"Marcel","family":"\u00c9mond","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec, H\u00f4pital de l\u2019Enfant\u2010J\u00e9sus Qu\u00e9bec City Qu\u00e9bec Canada"},{"name":"Division of Emergency Medicine Universit\u00e9 Laval Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-6408","authenticated-orcid":false,"given":"Ian G.","family":"Stiell","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Ottawa Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute Ottawa Ontario 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