{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:37:35Z","timestamp":1774363055762,"version":"3.50.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent studies have reported that dihydropyridine calcium channel blockers (dCCBs) may increase the risk of pancreatic cancer, but these studies had methodological limitations. We thus aimed to determine whether dCCBs are associated with an increased risk of pancreatic cancer compared with thiazide diuretics, a clinically relevant comparator.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted a new user, active comparator, population\u2010based cohort study using the UK Clinical Practice Research Datalink. We identified new users of dCCBs and new users of thiazide diuretics between 1990 and 2018, with follow\u2010up until 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% CIs for pancreatic cancer, comparing dCCBs with thiazide diuretics. Models were weighted using standardized morbidity ratio weights based on calendar time\u2010specific propensity scores. We also conducted secondary analyses by cumulative duration of use, time since initiation, and individual drugs and assessed for the presence of effect modification by age, sex, smoking status, body mass index, history of chronic pancreatitis, and diabetes. The cohort included 344\u2009480 initiators of dCCBs and 357\u2009968 initiators of thiazide diuretics, generating 3\u2009360\u2009745 person\u2010years of follow\u2010up. After a median follow\u2010up of 4.5\u2009years, the weighted incidence rate per 100\u2009000 person\u2010years was 37.2 (95% CI, 34.1\u201340.4) for dCCBs and 39.4 (95% CI, 36.1\u201342.9) for thiazide diuretics. Overall, dCCBs were not associated with an increased risk of pancreatic cancer (weighted HR, 0.93; 95% CI, 0.80\u20131.09). Similar results were observed in secondary analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this large, population\u2010based cohort study, dCCBs were not associated with an increased risk of pancreatic cancer compared with thiazide diuretics. These findings provide reassurance regarding the long\u2010term pancreatic cancer safety of these drugs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.122.026789","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:38:29Z","timestamp":1671017909000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Dihydropyridine Calcium Channel Blockers and Risk of Pancreatic Cancer: A Population\u2010Based Cohort Study"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-0998","authenticated-orcid":false,"given":"Julie","family":"Rouette","sequence":"first","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute, Jewish General Hospital Montreal Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-0624","authenticated-orcid":false,"given":"Emily G.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine McGill University Health Centre Montreal Canada"},{"name":"Division of Experimental Medicine McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University Montreal Canada"},{"name":"Department of Family Medicine McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-6875","authenticated-orcid":false,"given":"James M.","family":"Brophy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University Montreal Canada"},{"name":"Division of Clinical Epidemiology McGill University Health Centre\u2013Research Institute Montreal Canada"},{"name":"Department of Medicine McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-3556","authenticated-orcid":false,"given":"Laurent","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology Lady Davis Institute, Jewish General Hospital Montreal Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University Montreal Canada"},{"name":"Gerald Bronfman Department of Oncology McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.01.029"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-057510"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001961"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.02.086"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f3ef5e"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70260-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00033-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.13.1000"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7080197"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0562-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040771"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.5.1091"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000701)89:1<165::AID-CNCR21>3.0.CO;2-G"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16435"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3512"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.5.8462787"},{"key":"e_1_3_2_20_2","first-page":"713","article-title":"Calcium channel blockers and cancer: is an association biologically plausible?","volume":"9","author":"Daling JR","year":"1996","unstructured":"Daling JR. 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