{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:16:46Z","timestamp":1792624606029,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Abnormalities in left atrial (LA) function often occur before LA structural changes and clinically identified atrial fibrillation (AF). Little is known about the relationship between LA strain and the risk of subclinical atrial arrhythmias detected from extended ambulatory cardiac monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 1441 participants of MESA (Multi\u2010Ethnic Study of Atherosclerosis) completed speckle\u2010tracking echocardiography and cardiac monitoring during 2016 to 2018 (mean age, 73\u2009years); participants in AF during echocardiography or during the entire cardiac monitoring period were excluded. Absolute values of LA reservoir, booster pump, and conduit strains were measured. We evaluated associations of LA strain with monitor\u2010detected AF, premature atrial contractions, and supraventricular tachycardia. Primary analyses adjusted for demographic variables, blood pressure, diabetes, smoking, and clinical cardiovascular disease. Cardiac monitoring (median, 14\u2009days) detected AF in 3%. Each SD (4.0%) lower (worse) LA booster pump strain was associated with 84% higher risk of monitor\u2010detected AF (95% CI, 30%\u2013162%), 39% higher premature atrial contraction frequency (95% CI, 27%\u201353%), and 19% higher supraventricular tachycardia frequency (95% CI, 10%\u201329%). Additional adjustment for NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide), LA volume index, tissue Doppler a\u2032 peak velocity, left ventricular ejection fraction, and global longitudinal strain had little impact on associations. Findings were similar for LA reservoir strain and null for LA conduit strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a multiethnic community\u2010based cohort, impaired LA strain was an important correlate of subclinical atrial arrhythmias, even after adjustment for conventional measures of LA structure and function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.122.026875","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T06:49:20Z","timestamp":1667198960000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Left Atrial Strain and the Risk of Atrial Arrhythmias From Extended Ambulatory Cardiac Monitoring: MESA"],"prefix":"10.1161","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-0965","authenticated-orcid":false,"given":"Matthew P.","family":"Huber","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Washington School of Medicine Seattle WA"},{"name":"Cardiovascular Health Research Unit University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A.","family":"Pandit","sequence":"additional","affiliation":[{"name":"Division of Digital Medicine Scripps Research and Translational Institute La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington Seattle WA"},{"name":"Division of General Internal Medicine, Department of Medicine University of Washington School of Medicine Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-1279","authenticated-orcid":false,"given":"Kerri L.","family":"Wiggins","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington Seattle WA"},{"name":"Division of General Internal Medicine, Department of Medicine University of Washington School of Medicine Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-5554","authenticated-orcid":false,"given":"Ravi B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Freed","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain G.","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Wake Forest University School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-8201","authenticated-orcid":false,"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-512X","authenticated-orcid":false,"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington Seattle WA"},{"name":"Department of Epidemiology University of Washington School of Public Health Seattle 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